DCC-2036 (Rebastinib)

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Names

[ CAS No. ]:
1020172-07-9

[ Name ]:
DCC-2036 (Rebastinib)

[Synonym ]:
N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea
DCC2036
2-Pyridinecarboxamide, 4-[4-[[[[3-(1,1-dimethylethyl)-1-(6-quinolinyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
Rebastinib
4-[3-Fluoro-4-({[3-(2-methyl-2-propanyl)-1-(6-quinolinyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]-N-methyl-2-pyridinecarboxamide
4-[4-({[3-Tert-Butyl-1-(Quinolin-6-Yl)-1h-Pyrazol-5-Yl]carbamoyl}amino)-3-Fluorophenoxy]-N-Methylpyridine-2-Carboxamide
Rebastinib [USAN]
1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
4-(4-(3-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
DP-1919
DCC-2036

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
666.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H28FN7O3

[ Molecular Weight ]:
553.587

[ Flash Point ]:
357.0±31.5 °C

[ Exact Mass ]:
553.223755

[ PSA ]:
126.55000

[ LogP ]:
4.90

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.655

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide
  • 6-Hydroxyquinoline
  • 6-quinolinyl trifluoromethanesulfonate
  • Pivaloylacetonitrile
  • 4-Amino-3-fluorophenol
  • N-Methyl-4-chloropyridine-2-carboxamide
  • 4-Chlorpyridin-2-carbonylchlorid

DownStream

Related Compounds

  • 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide,4-methylbenzenesulfonic acid
  • DCC-2618
  • DCC-2618
  • DCC-3014
  • PERINDOPRILAT-DCC ACYLGUANIDINE
  • 5-methyl-5-propyl-1,3-oxazinane-2,4-dithione
  • 2-(3-{[(3-Chloropyridin-2-yl)oxy]methyl}piperidin-1-yl)acetamide
  • 2,2-dimethyl-N-{1-[2-oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]piperidin-4-yl}propanamide
  • N-cyclopropyl-4-[(pyridin-4-yl)methyl]morpholine-2-carboxamide
  • 2-Methoxy-6-(3-{octahydrocyclopenta[c]pyrrol-2-yl}azetidin-1-yl)pyridine
  • 2-Methoxy-4-(3-{octahydrocyclopenta[c]pyrrol-2-yl}azetidin-1-yl)pyridine
  • 3-Chloro-2-({1-[(oxolan-3-yl)methyl]piperidin-3-yl}methoxy)pyridine
  • 3-{4-[(5-Chloropyrimidin-2-yl)(methyl)amino]piperidin-1-yl}-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
  • 3-[5-(5-Chloropyridin-2-yl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
  • [(1H-1,3-benzodiazol-2-yl)methyl][(2,4-dichlorophenyl)methyl]methylamine
  • 4-methyl-2-(3-{[2-(propan-2-yl)-1H-imidazol-1-yl]methyl}azetidin-1-yl)-1,3-thiazole
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