3-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-methylpropanamide

Names

[ CAS No. ]:
102128-78-9

[ Name ]:
3-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-methylpropanamide

[Synonym ]:
1205 i.s.

Chemical & Physical Properties

[ Density]:
1.136g/cm3

[ Boiling Point ]:
451.7ºC at 760 mmHg

[ Molecular Formula ]:
C13H18N2O3

[ Molecular Weight ]:
250.29400

[ Flash Point ]:
227ºC

[ Exact Mass ]:
250.13200

[ PSA ]:
63.08000

[ LogP ]:
1.78330

[ Vapour Pressure ]:
2.38E-08mmHg at 25°C

[ Index of Refraction ]:
1.524

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE3097200
CHEMICAL NAME :
Propionamide, 3-(((1,4-benzodioxan-2-yl)methyl)amino)-N-methyl-
CAS REGISTRY NUMBER :
102128-78-9
LAST UPDATED :
198910
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H18-N2-O3
MOLECULAR WEIGHT :
250.33
WISWESSER LINE NOTATION :
T66 BO EOT&J C1M2VM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,317,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,317,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,317,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,317,1956 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
100 mg/kg
SEX/DURATION :
female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

Related Compounds

  • {6-Cyclopropanecarbonyl-6-azabicyclo[3.2.1]octan-5-yl}methanamine
  • 5-(aminomethyl)-N-(2-methylbutan-2-yl)-6-azabicyclo[3.2.1]octane-6-carboxamide
  • [1-(3-methylcyclopentyl)-1H-1,2,3-triazol-4-yl]methanamine
  • 3-(aminomethyl)-N-ethyl-N-propylcyclohexan-1-amine
  • [1-(4,4-dimethylcyclohexyl)-1H-1,2,3-triazol-4-yl]methanamine
  • (1r,3r)-3-{[Bis(propan-2-yl)amino]methyl}cyclobutan-1-amine
  • N-[4-(aminomethyl)oxan-4-yl]-2-cyclopropyl-N-methylacetamide
  • 5-[4-(Propan-2-yl)-1,3-thiazol-2-yl]pyrimidin-2-amine
  • 3-[1-(3-methylbutyl)-1H-1,2,3-triazol-4-yl]aniline
  • 2-(1-butyl-1H-1,2,3-triazol-4-yl)aniline
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