Naringin

Suppliers

Names

[ Name ]:
Naringin

[Synonym ]:
2,6-Dimethylpyrimidin-4(1H)-one
2,6-Dimethylpyrimidin-4-ol
Naringenin 7-neohesperidoside
MFCD00148888
2,6-Dimethyl-4(1H)-pyrimidinone
T6N CNJ B1 DQ F1
T6VM DNJ C1 E1
EINECS 233-566-4
2,6-Dimethyl-4(3H)-pyrimidinone
Naringenin 7-Rhamnoglucoside Hydrate
Naringenoside
Nobiletin
Naringin Hydrate
2,6-Dimethylpyrimidin-4(3H)-one
4(3H)-Pyrimidinone, 2,6-dimethyl-
4-pyrimidinol, 2,6-dimethyl-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
928.1±65.0 °C at 760 mmHg

[ Melting Point ]:
166 °C

[ Molecular Formula ]:
C₂₇H₃₂O₁₄

[ Molecular Weight ]:
580.53

[ Flash Point ]:
308.5±27.8 °C

[ PSA ]:
225.06000

[ LogP ]:
-0.18

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.564

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN6340000

CHEMICAL NAME :: Naringin

CAS REGISTRY NUMBER :: 10236-47-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H32-O14

MOLECULAR WEIGHT :: 580.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QN6340000

Precursor & DownStream

Precursor

DownStream

Phloretin
Acacetin
D-glucopyranose
2-O-α-L-rhamonopyranosyl-D-glucopyranose
Naringenin
Isosakuranetin
7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one
Naringin dihydrochalcone
Rhoifolin

Articles

Preconditioning L6 Muscle Cells with Naringin Ameliorates Oxidative Stress and Increases Glucose Uptake.

PLoS ONE 10 , e0132429, (2015)

Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have i...

Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.

PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin.

Food Chem. Toxicol. 81 , 160-70, (2015)

Phenolic compounds not only contribute to the sensory qualities of fruits and vegetables but also exhibit several health protective properties. Limonene and naringin are the most popular phenolics fou...