Jasplakinolide

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Names

[ Name ]:
Jasplakinolide

[Synonym ]:
(4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
Jaspamide
jasplakinolide
jasplakinolide,jaspis johnstoni
1-Oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone, 7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-, (4R,7R,10S,13S,15E,17R,19S)-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
968.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₄₅BrN₄O₆

[ Molecular Weight ]:
709.670

[ Flash Point ]:
539.4±34.3 °C

[ Exact Mass ]:
708.252258

[ PSA ]:
140.83000

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.553

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
UN 3172

[ RTECS ]:
GX7000000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.

PLoS ONE 6 , e20878, (2011)

Abnormal mitochondrial function is a widely reported contributor to neurodegenerative disease including Alzheimer's disease (AD), however, a mechanistic link between mitochondrial dysfunction and the ...

P2Y2 receptor signaling in neutrophils is regulated from inside by a novel cytoskeleton-dependent mechanism.

Exp. Cell Res. 336 , 242-52, (2015)

Functional selectivity, a process by which G-protein coupled receptors (GPCRs) can activate one signaling route while avoiding another, is regulated by ligand-mediated stabilization of specific recept...

Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli.

Mol. Biol. Cell 23(18) , 3663-72, (2012)

Fertilization changes the structure and function of the cell surface. In sea urchins, these changes include polymerization of cortical actin and a coincident, switch-like increase in the activity of t...

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