5-Methyl-1H-indole-2-carboxylic acid

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Names

[ CAS No. ]:
10241-97-1

[ Name ]:
5-Methyl-1H-indole-2-carboxylic acid

[Synonym ]:
5-Methyl-1H-indole-2-carboxylic acid
MFCD00047166
1H-Indole-2-carboxylic acid, 5-methyl-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
421.2±25.0 °C at 760 mmHg

[ Melting Point ]:
236-238°C (dec.)

[ Molecular Formula ]:
C10H9NO2

[ Molecular Weight ]:
175.184

[ Flash Point ]:
208.5±23.2 °C

[ Exact Mass ]:
175.063324

[ PSA ]:
53.09000

[ LogP ]:
2.77

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.696

MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Precursor

  • 2-Iodo-4-methylaniline
  • Pyruvic acid
  • Propanoic acid, 2-[(4-methylphenyl)hydrazono]-, ethyl ester, (E)

DownStream

  • 5-Methylindole
  • 1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE
  • 1H-Indole-2-carbonylchloride,5-methyl-(9CI)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The first potent and selective non-imidazole human histamine H4 receptor antagonists.

J. Med. Chem. 46 , 3957-3960, (2003)

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted i...

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Bioorg. Med. Chem. Lett. 20 , 6483, (2010)

Structure-guided techniques were used to evolve a 5-pyridinyl pyrazole-3-carboxylate fragment into a series of 5-aryl-carbamoyl-3-phenyl-imidazole-4-carboxylates, examples of which inhibited the Pin1 ...


More Articles


Related Compounds

  • 7-Amino-5-methyl-1H-indole-2-carboxylic acid
  • 3-amino-5-methyl-1H-indole-2-carboxylic acid
  • 7-Bromo-5-methyl-1H-indole-2-carboxylic acid
  • 3-Ethyl-5-methyl-1H-indole-2-carboxylic acid
  • 3-Formyl-5-methyl-1H-indole-2-carboxylic acid
  • 6-fluoro-5-methyl-1H-indole-2-carboxylic acid
  • 3-Imidazol-1-ylcyclobutan-1-ol;hydrochloride
  • (1-Ethynylcyclobutyl)methanamine;hydrochloride
  • 1-[(4-Methoxyphenyl)methyl]-3-methylpyrrolidin-2-one
  • (3Ar,6aS)-1,2,3,3a,4,6a-hexahydrofuro[3,4-b]pyrrol-6-one;hydrochloride
  • 2-[(2,2-Dimethyl-3,4-dihydrochromen-5-yl)oxymethyl]-1-(2-methylpropyl)aziridine
  • 2-Chloro-5-[(1-cyclobutylaziridin-2-yl)methoxy]benzonitrile
  • 1-[3-[(1-Cyclobutylaziridin-2-yl)methoxy]phenyl]imidazole
  • 3-[(1-Cyclobutylaziridin-2-yl)methoxy]-5-methoxybenzonitrile
  • 1-[4-[(1-Cyclobutylaziridin-2-yl)methoxy]phenyl]triazole
  • 5-Ethynyl-1,2-dimethoxy-3-nitrobenzene
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