N,O-Didansyl-L-tyrosine cyclohexylammonium salt

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Names

[ CAS No. ]:
102783-47-1

[ Name ]:
N,O-Didansyl-L-tyrosine cyclohexylammonium salt

[Synonym ]:
cyclohexanamine,(2S)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-[4-[5-(dimethylamino)naphthalen-1-yl]sulfonyloxyphenyl]propanoic acid

Chemical & Physical Properties

[ Molecular Formula ]:
C39H46N4O7S2

[ Molecular Weight ]:
746.93500

[ Exact Mass ]:
746.28100

[ PSA ]:
176.10000

[ LogP ]:
9.39750

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.

Chem. Biol. 8 , 981-995, (2001)

Protein plasticity in response to ligand binding abrogates the notion of a rigid receptor site. Thus, computational docking alone misses important prospective drug design leads. Bacterial-specific inh...

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

J. Med. Chem. 48 , 913-916, (2005)

N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase. The N-dansyl structure modulation led to a...

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.

ChemBioChem. 9 , 779-790, (2008)

The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication are important targets f...


More Articles

Related Compounds

  • N,O-didansyl-L-tyrosine
  • N-O-NITROPHENYLSULFENYL-L-TYROSINE DI(CYCLOHEXYL)AMMONIUM SALT
  • N-o-Dicarbobenzoxy-L-tyrosine
  • N,O-Diacetyl-L-tyrosine
  • N,O-dibenzoyl-L-tyrosine
  • N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester
  • N-(2-chlorobenzyl)-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)acetamide
  • 2-[2-(3-acetamidoanilino)-2-oxoethyl]sulfanyl-1-methyl-6-oxo-N-phenylpyrimidine-5-carboxamide
  • 2-((2-(benzylamino)-2-oxoethyl)thio)-1-methyl-6-oxo-N-(p-tolyl)-1,6-dihydropyrimidine-5-carboxamide
  • N-(4-methoxyphenyl)-1-methyl-2-((2-((5-methylisoxazol-3-yl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carboxamide
  • 2-tert-Butyl-5-nitroisoindoline
  • N-(3-methoxyphenyl)-1-methyl-6-oxo-2-((2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)thio)-1,6-dihydropyrimidine-5-carboxamide
  • N-(2-methoxyphenyl)-1-methyl-6-oxo-2-((2-oxo-2-(phenethylamino)ethyl)thio)-1,6-dihydropyrimidine-5-carboxamide
  • 1-(1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-oxopyrrolidin-3-yl)-3-methylurea
  • 1-(1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-oxopyrrolidin-3-yl)-3-isopropylurea
  • 1-(1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-oxopyrrolidin-3-yl)urea
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