N,O-Didansyl-L-tyrosine cyclohexylammonium salt

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Names

[ CAS No. ]:
102783-47-1

[ Name ]:
N,O-Didansyl-L-tyrosine cyclohexylammonium salt

[Synonym ]:
cyclohexanamine,(2S)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-[4-[5-(dimethylamino)naphthalen-1-yl]sulfonyloxyphenyl]propanoic acid

Chemical & Physical Properties

[ Molecular Formula ]:
C39H46N4O7S2

[ Molecular Weight ]:
746.93500

[ Exact Mass ]:
746.28100

[ PSA ]:
176.10000

[ LogP ]:
9.39750

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.

Chem. Biol. 8 , 981-995, (2001)

Protein plasticity in response to ligand binding abrogates the notion of a rigid receptor site. Thus, computational docking alone misses important prospective drug design leads. Bacterial-specific inh...

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

J. Med. Chem. 48 , 913-916, (2005)

N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase. The N-dansyl structure modulation led to a...

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.

ChemBioChem. 9 , 779-790, (2008)

The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication are important targets f...


More Articles

Related Compounds

  • N,O-didansyl-L-tyrosine
  • N-O-NITROPHENYLSULFENYL-L-TYROSINE DI(CYCLOHEXYL)AMMONIUM SALT
  • N-o-Dicarbobenzoxy-L-tyrosine
  • N,O-Diacetyl-L-tyrosine
  • N,O-dibenzoyl-L-tyrosine
  • N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester
  • N-[3-[4-(Difluoromethoxy)phenyl]-1-methylpropyl]-1H-1,2,4-triazole-5-methanamine
  • (4-Methyl-6-(pyrrolidin-1-yl)pyridin-3-yl)(phenyl)methanone
  • 3-(N-tert-butylacetamido)propanoic acid
  • 1-(4-Methyl-6-(pyrrolidin-1-yl)pyridin-3-yl)propan-1-ol
  • Methyl 2-azabicyclo[3.1.0]hexane-1-carboxylate
  • (4-Methyl-6-(pyrrolidin-1-yl)pyridin-3-yl)(phenyl)methanol
  • Ethyl-(1-methyl-1H-indol-4-ylmethyl)-amine
  • Methyl 4-methyl-6-(piperidin-1-yl)nicotinate
  • n-((3-(Tert-butyl)-1-methyl-1h-1,2,4-triazol-5-yl)methyl)ethanamine
  • (4-Methyl-6-(piperidin-1-yl)pyridin-3-yl)methanol
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