4'-Methylsulphonylacetophenone

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Names

[ CAS No. ]:
10297-73-1

[ Name ]:
4'-Methylsulphonylacetophenone

[Synonym ]:
4-Methylsulphonylacetophenone
MFCD00025072
EINECS 233-672-0
4-(Methylsulfonyl)Acetophenone
4-Acetophenone methyl sulfone
1-(4-(Methylsulphonyl)phenyl)ethan-1-one
1-[4-(methylsulfonyl)phenyl]ethan-1-one
1-[4-(Methylsulfonyl)phenyl]ethanone
Ethanone, 1-(4-methylsulfonylphenyl)-
Ethanone, 1-[4-(methylsulfonyl)phenyl]-
1-(4-methylsulfonylphenyl)ethanone
Etoricoxib Impurity 19
4'-Methylsulphonylacetophenone

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
385.4±34.0 °C at 760 mmHg

[ Melting Point ]:
126-129 °C(lit.)

[ Molecular Formula ]:
C9H10O3S

[ Molecular Weight ]:
198.24

[ Flash Point ]:
242.0±18.3 °C

[ Exact Mass ]:
198.035065

[ PSA ]:
59.59000

[ LogP ]:
0.40

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.521

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(Methylthio)acetophenone
  • 1-(4-Iodophenyl)ethanone
  • Sodium methanesulfinate
  • Dichloromethane
  • 1-(4-Bromophenyl)ethanone
  • Acetophenone
  • 4-Acetylphenylboronic acid
  • Thioanisole
  • 1-(4-Methanesulfinylphenyl)ethan-1-one

DownStream

  • 4-Methylsulfonyl phenyl acetic acid
  • 2-Bromo-1-[4-(methylsulfonyl)phenyl]ethanone
  • [2-(4-methylsulfonylphenyl)-2-oxoethyl] 2-phenylacetate
  • 2-(4-(METHYLSULFONYL)PHENYL)IMIDAZO[1,2-A]PYRIMIDINE
  • Rofecoxib
  • 3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one
  • 2-HYDROXY-1-(4-(METHYLSULFONYL)PHENYL)ETHANONE
  • 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
  • 3-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)prop-2-en-1-one
  • 3-(4-methoxyphenyl)-1-(4-methylsulfonylphenyl)prop-2-en-1-one

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents.

J. Natl. Cancer Inst. 94(23) , 1745-57, (2002)

The cyclooxygenase-2 (COX-2) inhibitor celecoxib is thought to act as a chemopreventive agent by sensitizing cancer cells to apoptotic signals. Other COX-2 inhibitors, such as rofecoxib, are two order...

Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors

Eur. J. Med. Chem. 45 , 6135-8, (2010)

Eighteen new 1-N-substituted-3,5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been evaluated. The results of these biological...

New Antibacterial Agents. II. An Alternate Synthesis of DL-threo-2-Dichloro-acetamido-1-(4-methylsulfonylphenyl)-1, 3-propanediol1. Suter CM, et al.

J. Am. Chem. Soc. 75(17) , 4330-4333, (1953)


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Related Compounds

  • 4'-PYRROLIDINOMETHYL-2-THIOMETHYLBENZOPHENONE
  • 4'-Amylphenyl-4-methoxybenzoate
  • 4'-BROMO-3-(4-CHLOROPHENYL)PROPIOPHENONE
  • 4'-CHLORO-3-(3-CHLORO-5-FLUOROPHENYL)-3'-FLUOROPROPIOPHENONE
  • 4'-O-tert-Butyldimethylsilyl Genistein
  • 4'- (trifluoromethyl)- [1,1'- [BIPHENYL]-2-CARBONYL] chloride
  • (+)-3-[5-(Acetyloxy)pentyl]cycloheptanone
  • 4-(3-(6-phenyl-3,4-dihydro-1H-benzo[4,5]imidazo[1,2-a][1,3,5]triazino[1,2-c][1,3,5]triazin-2(6H)-yl)propyl)morpholine
  • Ethyl 2-[(cyanomethyl)sulfanyl]-5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
  • 5-[(1,3-Benzoxazol-2-ylsulfanyl)methyl]-2-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
  • 2-(5,7-dimethoxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)acetamide
  • ethyl 5-chloro-2-(4-methoxybenzyl)-2H-1,2,3-triazole-4-carboxylate
  • N-benzyl-2-{[6-tert-butyl-3-cyano-4-(trifluoromethyl)pyridin-2-yl]sulfanyl}acetamide
  • (2E)-2-[(1-methyl-1H-indol-3-yl)methylidene]-3-oxo-2,3-dihydro-1-benzofuran-6-yl 3,4-dimethoxybenzoate
  • (2Z)-2-(3-bromobenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl 4-fluorobenzenesulfonate
  • 1-(1-Benzyl-pyrrolidin-3-yl)-3-(2-methyl-quinolin-4-yl)-urea
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