4'-Methylsulphonylacetophenone
Suppliers
Names
[ CAS No. ]:
10297-73-1
[ Name ]:
4'-Methylsulphonylacetophenone
[Synonym ]:
4-Methylsulphonylacetophenone
MFCD00025072
EINECS 233-672-0
4-(Methylsulfonyl)Acetophenone
4-Acetophenone methyl sulfone
1-(4-(Methylsulphonyl)phenyl)ethan-1-one
1-[4-(methylsulfonyl)phenyl]ethan-1-one
1-[4-(Methylsulfonyl)phenyl]ethanone
Ethanone, 1-(4-methylsulfonylphenyl)-
Ethanone, 1-[4-(methylsulfonyl)phenyl]-
1-(4-methylsulfonylphenyl)ethanone
Etoricoxib Impurity 19
4'-Methylsulphonylacetophenone
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
385.4±34.0 °C at 760 mmHg
[ Melting Point ]:
126-129 °C(lit.)
[ Molecular Formula ]:
C9H10O3S
[ Molecular Weight ]:
198.24
[ Flash Point ]:
242.0±18.3 °C
[ Exact Mass ]:
198.035065
[ PSA ]:
59.59000
[ LogP ]:
0.40
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.521
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2914700090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
J. Natl. Cancer Inst. 94(23) , 1745-57, (2002)
The cyclooxygenase-2 (COX-2) inhibitor celecoxib is thought to act as a chemopreventive agent by sensitizing cancer cells to apoptotic signals. Other COX-2 inhibitors, such as rofecoxib, are two order...
Eur. J. Med. Chem. 45 , 6135-8, (2010)
Eighteen new 1-N-substituted-3,5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been evaluated. The results of these biological...
New Antibacterial Agents. II. An Alternate Synthesis of DL-threo-2-Dichloro-acetamido-1-(4-methylsulfonylphenyl)-1, 3-propanediol1. Suter CM, et al.J. Am. Chem. Soc. 75(17) , 4330-4333, (1953)