Benzyl cinnamate

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Names

[ CAS No. ]:
103-41-3

[ Name ]:
Benzyl cinnamate

[Synonym ]:
Cinnamic Acid Benzyl Ester
benzyl trans-3-phenylpropenoate
2-Propenoic acid, 3-phenyl-, phenylmethyl ester, (E)-
FEMA 2142
Benzyl (2E)-3-phenyl-2-propenoate
benzyl (2E)-3-phenylprop-2-enoate
Benzyl Alcohol Cinnamate
2-Propenoic acid, 3-phenyl-, phenylmethyl ester, (2E)-
Benzyl cinnamate
Benzyl γ-phenylacrylate
EINECS 203-109-3
Benzyl ciamate
CINNAMEIN
benzylalcohol,cinnamate
Phenylmethyl cinnamate
Benzyl g-Phenylacrylate
MFCD00004789
Benzyl (2E)-3-phenylacrylate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
195-200 ºC (5 mmHg)

[ Melting Point ]:
34-37 °C(lit.)

[ Molecular Formula ]:
C16H14O2

[ Molecular Weight ]:
238.281

[ Flash Point ]:
225.7±10.4 °C

[ Exact Mass ]:
238.099380

[ PSA ]:
26.30000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.4025-1.4045

[ Water Solubility ]:
PRACTICALLY INSOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD8400000
CHEMICAL NAME :
Cinnamic acid, benzyl ester
CAS REGISTRY NUMBER :
103-41-3
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C16-H14-O2
MOLECULAR WEIGHT :
238.30
WISWESSER LINE NOTATION :
R1U1VO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1017,1973 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5530 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3760 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - gastritis
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83174 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 456 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83174 No. of Facilities: 546 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 2855 (estimated) No. of Female Employees: 1107 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
3077

[ WGK Germany ]:
2

[ RTECS ]:
GD8400000

[ HS Code ]:
29163900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Cinnamic acid
  • Benzyl alcohol
  • (2E)-3-(2-chlorophenyl)prop-2-enal
  • Methyl cinnamate
  • α-Bromocinnamaldehyde
  • Cinnamic aldehyde
  • Benzyl bromide
  • Benzyl acrylate
  • Sodium benzenesulfinate
  • MONO-BENZYL MALONATE

DownStream

  • Hydrocinnamic acid
  • 2,3-dibenzylsuccinic acid
  • Methyl (2R)-2-hydroxy-3-phenylpropanoate
  • (S)-Methyl 2-hydroxy-3-phenylpropanoate
  • METHYL (2R,3S)-(+)-2,3-DIHYDROXY-3-PHENYLPROPIONATE
  • L-Phenylalanine
  • Cinnamic acid

Customs

[ HS Code ]: 29163900

Articles

Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells.

Eur. J. Med. Chem. 46 , 5498-511, (2011)

In the present study, we report the design and synthesis of novel analogs of cinnamates, thiocinnamates and thionocinnamates and evaluated the potencies of these analogs to inhibit TNF-α induced ICAM-...

Determination of UV filters and antimicrobial agents in environmental water samples.

Anal. Bioanal. Chem 387(4) , 1343-50, (2007)

Although there is increasing concern about residues from personal care products entering the aquatic environment and their potential to accumulate to levels that pose a health threat to humans and wil...

Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

J. Nat. Prod. 73 , 623-7, (2010)

Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7''R)-8-[1-(4'-hydroxy-3'-methoxyphen...


More Articles

Related Compounds

  • Benzyl cinnamate
  • Benzyl cinnamate
  • 3,5-diamino benzyl cinnamate
  • 3,5-bis(tert-butoxycarbonylamino)benzyl cinnamate
  • Benzyl 3-isothiocyanatophenyl ether
  • benzyl N-[1-phenyl-5-(pyrrol-1-yl)-1H-pyrazol-4-yl]carbamate