N-Ethylaniline

Suppliers

Names

[ CAS No. ]:
103-69-5

[ Name ]:
N-Ethylaniline

[Synonym ]:
N-Ethylaniline [UN2272] [Poison]
N-Ethyl-N-phenylamine
N-ethylbenzeneamine
Anilinoethane
EINECS 203-135-5
aniline, N-ethyl-
Benzenamine, N-ethyl-
N-Ethylaniline
ANILINE,N-ETHYL
p-Ethylaminobenzene
Benzenamine,N-ethyl
N-Ethylaminobenzene
N-Ethylbenzenamine
N-monoethylaniline
MFCD00009025
n-Ethyl aniline
Ethylaniline

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
201.7±9.0 °C at 760 mmHg

[ Melting Point ]:
-63 °C

[ Molecular Formula ]:
C₈H₁₁N

[ Molecular Weight ]:
121.180

[ Flash Point ]:
85.0±0.0 °C

[ Exact Mass ]:
121.089149

[ PSA ]:
12.03000

[ LogP ]:
2.13

[ Vapour density ]:
4.2 (vs air)

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.559

[ Stability ]:
Stable, but decomposes upon prolonged exposure to air or light. Combustible. Incompatible with strong oxidizing agents. May react violently with nitric acid.

[ Water Solubility ]:
50 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX9780000

CHEMICAL NAME :: Aniline, N-ethyl-

CAS REGISTRY NUMBER :: 103-69-5

BEILSTEIN REFERENCE NO. :: 0507468

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H11-N

MOLECULAR WEIGHT :: 121.20

WISWESSER LINE NOTATION :: 2MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1130 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0429

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 15,447,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 15,447,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 242 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(6),22,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84347 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 495 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331-H373

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R33:Danger of cumulative effects.

[ Safety Phrases ]:
S28-S37-S45-S28A

[ RIDADR ]:
UN 2272 6.1/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
BX9780000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Acetonitrile
ch3cho
nitrobenzene
Ethylamine
Fentin chloride
acetophenone oxime mesylate
Aziridine, 1-phenyl-
4-Bromoaniline
Glycerol

DownStream

3-chloro-N-ethyl-N-phenyl-1-benzothiophene-2-carboxamide
N-ethyl-5,5-dimethyl-N-phenyl-1,3,2-dioxaphosphinan-2-amine
(4-ethyl-1,1-dioxo-1λ6,2,4-benzothiadiazin-3-yl)hydrazine
4H-1,2,4-Benzothiadiazine,3-chloro-4-ethyl-, 1,1-dioxide
1-ethyl-2,4,4-tris(trifluoromethyl)quinazoline
5-Amino-N-ethyl-2-methyl-N-phenylbenzenesulphonamide
3,4-Dihydroisoquinoline
4-(Diethylamino)benzoic acid
n-ethyl-4-nitroaniline
n-ethyl-2-nitroaniline

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Spectroscopic studies of molecular interactions involving 2,6-diethylaniline and N-ethylaniline donors and iodine as an electron acceptor in different solvents.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 66(1) , 94-101, (2007)

The charge-transfer complexes of 2,6-diethylaniline (DEA) and N-ethylaniline (NEA) with iodine, as a typical sigma-acceptor were studied spectrophotometrically in chloroform, dichloromethane and carbo...