N-(2-Hydroxyethyl)piperazine

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Names

[ CAS No. ]:
103-76-4

[ Name ]:
N-(2-Hydroxyethyl)piperazine

[Synonym ]:
1-(2-Hydroxyethyl)piperazine
T6M DNTJ D2Q
N-(2-Hydroxyethyl)Piperazine
1-Piperazinethanol
2-Piperazin-1-ylethanol
N-(β-Hydroxyethyl)piperazine
4-(2-hydroxyethyl)-piperazine
EINECS 203-142-3
PIPERAZINE ETHANOL
2-(piperazin-1-yl)ethanol
Piperazinoethanol
MFCD00005970
2-(1-piperazinyl)-1-ethanol
usafdo-22
N-(2-hydroxy-ethyl)-piperazine
1-Piperazineethanol
2-(1-Piperazinyl)ethanol
(β-Hydroxyethyl)piperazine
1-(β-Hydroxyethyl)piperazine
N-(2-HYDROXYETHYL) PIPERAZINE

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
245.0±20.0 °C at 760 mmHg

[ Melting Point ]:
-38.5 °C

[ Molecular Formula ]:
C₆H₁₄N₂O

[ Molecular Weight ]:
130.19

[ Flash Point ]:
101.9±21.8 °C

[ Exact Mass ]:
130.110611

[ PSA ]:
35.50000

[ LogP ]:
-0.45

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.475

[ Water Solubility ]:
MISCIBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6825000

CHEMICAL NAME :: 1-Piperazineethanol

CAS REGISTRY NUMBER :: 103-76-4

BEILSTEIN REFERENCE NO. :: 0104361

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C6-H14-N2-O

MOLECULAR WEIGHT :: 130.22

WISWESSER LINE NOTATION :: T6M DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/6/1970

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,865,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4920 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/6/1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3720 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R38;R41

[ Safety Phrases ]:
S26-S36/39-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
TL6825000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-BOC-4-(2-hydroxyethyl)piperazine
2-(4-prop-2-enylpiperazin-1-yl)ethanol
Triethanolamine
ETHYLENE OXIDE
Piperazine
2-Aminoethanol
1,2-Ethanediamine
2-Indoethanol

DownStream

CHEMPACIFIC 41241
1-[4-(2-hydroxyethyl)piperazin-1-yl]-4-(2-hydroxy-5-methoxyphenyl)-4-phenylbutan-1-one
2-(4-benzhydrylpiperazin-1-yl)ethanol
2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol
2,2,3,3,5,5,6,6-octafluoro-4-(1,1,2,2,2-pentafluoroethyl)morpholine
Perfluor-N-methyl-N,N-diethylamine
Tris(pentafluoroethyl)amine
2-(4-Methyl-1-piperazinyl)ethanol
2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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N-(2-Hydroxyethyl)piperazine-d4
N-(2-hydroxyethyl)piperazine hydrochloride
N-(2-Hydroxyethyl)piperazine-N'-(4-butanesulfonic acid)
N-(2-HYDROXYETHYL)PIPERAZINE-N-(2-ETHANESULFONICACID)HEMISODIUMSALT
N-(2-Hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid) potassium salt
Urethane d'enol de la phenylbutazone et de la N-(2-hydroxyethyl)piperazine
4-Chloro-3-fluorophenyl-(1-methyl-2-pyrrolyl)methanol
6-bromo-N-[4-(ethylcarbamoyl)phenyl]-3-methylpyridine-2-carboxamide
4-(3,5-Dimethylpiperidin-1-yl)benzene-1,3-diamine
3-(3-Chlorobenzyl)-4-phenylpyrrolidin-2-one
(2R)-2-cyclohexyl-2-(dimethylamino)aceticacid
Tert-butyl 4-phenoxypiperidine-4-carboxylate
2-(2-Methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1-ethyl-N~3~-(2-furylmethyl)-1H-pyrazole-3,4-diamine
6-(3-Amino-5-fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine
N-(1-cyanocyclohexyl)-5-nitro-1-benzothiophene-2-carboxamide

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