2-Amino-6-chloropurine

Names

[ Name ]:
2-Amino-6-chloropurine

[Synonym ]:
2-Amino-6-Chloro-Purin
2-Amino-6-chloropurine
MFCD00075252
EINECS 233-686-7
6-Chloroguanine
9H-Purin-2-amine, 6-chloro-
6-Chloro-3H-purin-2-amine
2-AMINO-6-CHLORO-PURINE

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
315.2ºC at 760mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₅H₄ClN₅

[ Molecular Weight ]:
169.57

[ Flash Point ]:
144.4ºC

[ Exact Mass ]:
169.015518

[ PSA ]:
80.48000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
1.75E-15mmHg at 25°C

[ Index of Refraction ]:
1.827

[ Storage condition ]:
Keep Cold

[ Water Solubility ]:
1.7 g/L (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO7502000

CHEMICAL NAME :: Purine, 2-amino-6-chloro-

CAS REGISTRY NUMBER :: 10310-21-1

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H4-Cl-N5

MOLECULAR WEIGHT :: 169.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mg/L/24H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,149,1984

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UO7502000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

6-(2-methoxyethoxy)-7H-purin-2-amine
2-Iodoadenosine
Penciclovir
2'-C-Methylguanosine
2-(2-Amino-6-chloro-9H-purin-9-yl)acetic acid
6-(2-trimethylsilylethoxy)-7H-purin-2-amine
9-Allyl-6-chloro-9H-purin-2-ylamine
5-(2-amino-6-oxo-3H-purin-9-yl)pentanoic acid
N-BENZYL-2-CHLORO-9H-PURIN-6-AMINE

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.

Bioorg. Med. Chem. 15 , 3450-6, (2007)

Xanthine oxidase (XO) is a key enzyme which can catalyze xanthine to uric acid causing hyperuricemia in humans. By using the fractionation technique and inhibitory activity assay, an active compound t...

Molecular crowding enhances facilitated diffusion of two human DNA glycosylases.

Nucleic Acids Res. 43 , 4087-97, (2015)

Intracellular space is at a premium due to the high concentrations of biomolecules and is expected to have a fundamental effect on how large macromolecules move in the cell. Here, we report that crowd...

Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides.

J. Org. Chem. 74(6) , 2616-9, (2009)

Upon reacting 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal S-oxide (6) with Ac(2)O/TMSOAc/BF(3) x OEt(2) in CH(2)Cl(2), the additive Pummerer reaction proceeded to furnish the corresponding 1,2...