Pazinaclone

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Names

[ CAS No. ]:
103255-66-9

[ Name ]:
Pazinaclone

[Synonym ]:
8-[[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol]-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane
Pazinaclone
DN-2327
2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one
2-(7-Chloro-1,8-naphthyridine-2-yl)-3-[2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decane-8-yl)ethyl]isoindoline-1-one
2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-carbonylmethylisoindolin-1-one

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
712.5ºC at 760mmHg

[ Molecular Formula ]:
C25H23ClN4O4

[ Molecular Weight ]:
478.92800

[ Flash Point ]:
384.7ºC

[ Exact Mass ]:
478.14100

[ PSA ]:
84.86000

[ LogP ]:
3.74320

[ Vapour Pressure ]:
3.79E-20mmHg at 25°C

[ Index of Refraction ]:
1.709

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JG6717092
CHEMICAL NAME :
1,4-Dioxa-8-azaspiro(4.5)decane, 8-((2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3- oxo- 1H-isoindol-1-yl)acetyl)-
CAS REGISTRY NUMBER :
103255-66-9
LAST UPDATED :
199703
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H23-Cl-N4-O4
MOLECULAR WEIGHT :
478.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4695572

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxoisoindoline-1-acetic acid
  • Diethyl Cyanophosphonate
  • 4-Piperidone-ethylene ketal

DownStream

Related Compounds

  • Pazinaclone
  • 1,2,3,5-Tetramethylpiperazine
  • 5H-Indeno[1,2-c]pyridin-5-one, 7-chloro-
  • 4-Chloro-3-phenylisoxazolo[5,4-d]pyrimidine
  • (Isothiocyanatomethoxy)ethane
  • 2-[(But-3-yn-1-yloxy)methyl]oxirane
  • tert-butyl (5-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetate
  • Ethyl 2-phenyl-4-(2-phenylethyl)-5-thiazolecarboxylate
  • 2,4,6-Trimethyl-N-(1-phenylethylidene)benzenesulfonamide
  • N-(3-aminopropyl)-4-mercaptobenzamide
  • 1-propyl-1H-indole-5,6-diol
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