N-Methylisatoic Anhydride

Names

[ Name ]:
N-Methylisatoic Anhydride

[Synonym ]:
1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione
N-Methylisatoic Anhydride
MFCD00006815
1-methyl-3,1-benzoxazine-2,4-dione
EINECS 233-714-8

Chemical & Physical Properties

[ Density]:
1.348 g/cm3

[ Boiling Point ]:
297.5ºC at 760 mmHg

[ Melting Point ]:
165 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₇NO₃

[ Molecular Weight ]:
177.15700

[ Flash Point ]:
133.7ºC

[ Exact Mass ]:
177.04300

[ PSA ]:
52.21000

[ LogP ]:
0.49170

[ Vapour density ]:
6.1 (vs air)

[ Vapour Pressure ]:
0.00135mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
-20°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM3140000

CHEMICAL NAME :: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-

CAS REGISTRY NUMBER :: 10328-92-4

BEILSTEIN REFERENCE NO. :: 0383957

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O3

MOLECULAR WEIGHT :: 177.17

WISWESSER LINE NOTATION :: T66 BNVOVJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 34800 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DM3140000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Isatoic anhydride
methyl iodide
carbon monoxide
N-Methylaniline
Dimethyl sulfate
Anthranilic acid
1-methylisatin
N-Methylanthranilic acid
Methyl chloroformate
Ethyl chloroformate

DownStream

2-(hydroxymethyl)-1-methylquinolin-4-one
4-Hydroxy-1-methyl-3-(1-methyl-1H-benzimidazol-2-yl)-2(1H)-quinol inone
Ethyl 2-(methylamino)benzoate
1-methyl-2,2-diphenyl-indolin-3-one
2-METHYLAMINO-N-PHENETHYL-BENZAMIDE
1-methyl-3-phenyl-2-sulfanylidene-quinazolin-4-one
leucoline
9(10H)-Acridinone,10-methyl-
Roquinimex
methyl n-methylanthranilate

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Structure and function of echinoderm telomerase RNA.

RNA 22 , 204-15, (2016)

Telomerase is a ribonucleoprotein (RNP) enzyme that requires an integral telomerase RNA (TR) subunit, in addition to the catalytic telomerase reverse transcriptase (TERT), for enzymatic function. The ...

Simultaneous determination of myo-inositol and scyllo-inositol by MEKC as a rapid monitoring tool for inositol levels.

Electrophoresis 28(8) , 1221-8, (2007)

A simple and rapid MEKC method was developed for the simultaneous determination of myo-inositol, scyllo-inositol, and glucose. Prior to electrophoretic separation, the nonfluorescent inositols and glu...

Role of lysine binding residues in the global folding of the lysC riboswitch.

RNA Biol. 12 , 1372-82, (2016)

Riboswitches regulate gene expression by rearranging their structure upon metabolite binding. The lysine-sensing lysC riboswitch is a rare example of an RNA aptamer organized around a 5-way helical ju...