Tepoxalin

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Names

[ CAS No. ]:
103475-41-8

[ Name ]:
Tepoxalin

[Synonym ]:
Zubrin
Tepoxalinum [Latin]
3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide
1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-
5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide
Tepoxalin
Tepoxalin [USAN:INN]
Tepoxaline
Tepoxalina [Spanish]
Tepoxalina
3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
Tepoxaline [French]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
573.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H20ClN3O3

[ Molecular Weight ]:
385.844

[ Flash Point ]:
300.3±32.9 °C

[ Exact Mass ]:
385.119324

[ PSA ]:
67.59000

[ LogP ]:
3.84

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.610

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ8002500
CHEMICAL NAME :
1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-me thyl-
CAS REGISTRY NUMBER :
103475-41-8
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H20-Cl-N3-O3
MOLECULAR WEIGHT :
385.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1085 mg/kg/31D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7280 mg/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
54600 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Anisylhydrazine hydrochloride
  • 6-(4-CHLOROPHENYL)-4,6-DIOXOHEXANOIC ACID
  • 5-[2-(4-chlorophenyl)-2-oxoethylidene]oxolan-2-one
  • O-(N-methylamino)-6-(4-chlorophenyl)-4,6-dioxohexanoate
  • 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid
  • methylhydroxylammonium chloride

DownStream