1-Piperidinepropanol

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Names

[ CAS No. ]:
104-58-5

[ Name ]:
1-Piperidinepropanol

[Synonym ]:
3-Piperidino-1-propanol
3-piperidin-1-ylpropan-1-ol
3-(1-Piperidino)propanol
Piperidine-1-propanol
1-Propanol, 3-piperidino-
1-Piperidinepropanol
3-(piperidin-1-yl)propan-1-ol
3-(1-Piperidinyl)-1-propanol
MFCD00023781
EINECS 203-216-5
3-piperidino-propan-1-ol
3-Piperidinopropanol
1-Propanol,3-piperidino

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
237.9±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H17NO

[ Molecular Weight ]:
143.227

[ Flash Point ]:
105.6±21.3 °C

[ Exact Mass ]:
143.131012

[ PSA ]:
23.47000

[ LogP ]:
0.46

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.477

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN2414500
CHEMICAL NAME :
1-Piperidinepropanol
CAS REGISTRY NUMBER :
104-58-5
BEILSTEIN REFERENCE NO. :
0001275
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H17-N-O
MOLECULAR WEIGHT :
143.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
58 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 14,201,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7918 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 1440 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TN2414500

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperidine
  • 3-Chloro-1-propanol
  • METHYL 3-(PIPERIDIN-1-YL)PROPANOATE
  • Oxetane
  • Butylmagnesium Bromide
  • 3-Bromopropan-1-ol
  • 3-Iodopropanol
  • β-Propiolactone
  • 1-Piperidinepropanoicacid, ethyl ester
  • sodium allyloxide

DownStream

  • 1-(3-Chloropropyl)piperidine hydrochloride (1:1)
  • N-Methyl-3-(1-piperidinyl)-1-propanamine
  • BENZOIC ACID, 2-BUTOXY-4-BUTYLAMINO-, 3-PIPERIDINOPROPYL ESTER
  • Pitolisant
  • 1-(3-chloropropyl)piperidine
  • N-Ethyl-3-(1-piperidinyl)-1-propanamine
  • 2,3,4,6,7,8,9,9a-octahydropyrido[2,1-b][1,3]oxazine
  • 4-(3-piperidin-1-ylpropoxy)benzaldehyde
  • 1-Phenylcyclopentanecarboxylic acid 3-piperidinopropyl ester
  • 1-[3-(4-nitrophenoxy)propyl]piperidine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: High affinity and human/rat species-selective histamine H3 receptor antagonists

Bioorg. Med. Chem. Lett. 23(23) , 6415-20, (2013)

OUP-186: histamine H3R antagonist inactive in rats, but especially potent in humans.


More Articles

Related Compounds

  • 1-Piperidinepropanol
  • 1-Piperidinepropanol,b-phenyl
  • 1-Piperidinepropanol,2-methyl
  • 1-Piperidinepropanol, 4-amino-
  • 1-Piperidinepropanol,2-methyl-b-phenyl
  • 1-Piperidinepropanol, α-ethyl-α-phenyl-
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine