4-Methylbenzyl chloride

Names

[ CAS No. ]:
104-82-5

[ Name ]:
4-Methylbenzyl chloride

[Synonym ]:
Benzene, 1-(chloromethyl)-4-methyl-
α-Chloro-p-xylene
alpha-Chloro-p-xylene
4-Methyl benzyl chloride
EINECS 203-241-1
4-Methylbenzyl chloride
1-(Chloromethyl)-4-methylbenzene
MFCD00000919

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
198.6±9.0 °C at 760 mmHg

[ Melting Point ]:
4 °C(lit.)

[ Molecular Formula ]:
C₈H₉Cl

[ Molecular Weight ]:
140.610

[ Flash Point ]:
75.6±0.0 °C

[ Exact Mass ]:
140.039276

[ LogP ]:
2.95

[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.524

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE4030000

CHEMICAL NAME :: p-Xylene, alpha-chloro-

CAS REGISTRY NUMBER :: 104-82-5

BEILSTEIN REFERENCE NO. :: 0507387

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H9-Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S27-S36/37/39-S45-S37/39

[ RIDADR ]:
UN 2922 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
ZE4030000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

p-tolylmethanol
p-Tolualdehyde
p-(dimethoxymethyl)toluene
Formaldehyde
Toluene
Tolylacetic acid
4-Methyl-thiobenzylchlorid
(p-Me-benzyl)tributylstannane
p-Xylene

DownStream

2-[(4-METHYLBENZYL)THIO]ETHANAMINE
Diethyl (4-Methylbenzyl)phosphonate
4-[(4-Methylbenzyl)oxy]benzenecarboxylic acid
3-METHOXY-2-[(4-METHYLBENZYL)OXY]BENZALDEHYDE
4,4,5,5-TETRAMETHYL-2-(4-METHYLBENZYL)-1,3,2-DIOXABOROLANE
Benzene,1-methyl-4-[(4-methylphenyl)methyl]-
BENZENE,1-METHYL-2-[(4-METHYL)
(E)-1,2-Bis(4-methylphenyl)ethene
p-Xylene
1,2-di(p-tolyl)ethane

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives.

J. Appl. Toxicol. 3(4) , 203-7, (1983)

Benzyl chloride, benzyl bromide, p-methylbenzyl chloride, and p-nitrobenzyl chloride were used to study chemical reactivity with 4-(p-nitrobenzyl)-pyridine (NBP), and with guanosine in vitro, in relat...

Electrophilic attack at carbon-5 of guanine nucleosides: structure and properties of the resulting guanidinoimidazole products.

IARC Sci. Publ. (70) , 235-40, (1986)