4-Chlorobenzyl chloride

Suppliers

Names

[ CAS No. ]:
104-83-6

[ Name ]:
4-Chlorobenzyl chloride

[Synonym ]:
Benzene, 1-chloro-4- (chloromethyl)-
4-Chlorobenzyl chloride
EINECS 203-242-7
MFCD00000914
4-Chlorobenzylchloride
Toluene, p,α-dichloro-
Benzene, 1-chloro-4-(chloromethyl)-
α,4-Dichlorotoluene
1-Chloro-4-(chloromethyl)benzene
p-α-Dichlorotoluene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
223.0±0.0 °C at 760 mmHg

[ Melting Point ]:
27-29 °C(lit.)

[ Molecular Formula ]:
C7H6Cl2

[ Molecular Weight ]:
161.029

[ Flash Point ]:
97.8±0.0 °C

[ Exact Mass ]:
159.984650

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XT0720000
CHEMICAL NAME :
Toluene, p,alpha-dichloro-
CAS REGISTRY NUMBER :
104-83-6
BEILSTEIN REFERENCE NO. :
0471558
LAST UPDATED :
199710
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C7-H6-Cl2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1075 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1156 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10370 mg/kg/9W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83213 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 249 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83213 No. of Facilities: 43 (estimated) No. of Industries: 3 No. of Occupations: 21 No. of Employees: 5959 (estimated) No. of Female Employees: 763 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H317-H411

[ Precautionary Statements ]:
P273-P280

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R20/21/22;R34;R51/53

[ Safety Phrases ]:
S26-S36/37/39-S45-S29-S61

[ RIDADR ]:
UN 3427 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
XT0720000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • p-chlorobenzylalcohol
  • 4-Chlorobenzaldehyde
  • 4-Chlorobenzaldehyde dimethyl acetal
  • 4-Chlorophenylacetic acid
  • 4-Chlorotoluene
  • 4-chlorobenzyl hypochlorothioite
  • 1-chloro-4-(fluoromethylsulfanylmethyl)benzene
  • Toluene
  • 2-imidazol-1-yl-1-(4-phenylphenyl)ethanone
  • 4-CHLOROBENZYLMAGNESIUM CHLORIDE

DownStream

  • 2-[(4-chlorophenyl)methyl]-3,3-dimethylbutanoyl chloride
  • tert-butyl 2-[(4-chlorophenyl)methyl]-3,3-dimethylbutanoate
  • MP265
  • 2-Butanone,4-(4-chlorophenyl)-
  • Ethyl 4-chlorophenylalaninate hydrochloride (1:1)
  • 5-Bromo-2-[(4-chlorobenzyl)oxy]benzaldehyde
  • 9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
  • BENZENEPROPANENITRILE, 4-CHLORO-
  • 2-(4-Chlorophenyl)ethanol
  • 4-Chlorotoluene

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Tonic inhibition of thermoregulation in the decerebrate monkey (Saimiri sciureus).

Exp. Neurol. 64(3) , 632-48, (1979)

Tetrahedron 50 , 4087, (1994)

Synth. Commun. 24 , 2247, (1994)


More Articles

Related Compounds

  • 3-Fluoro-4-Chlorobenzyl Chloride
  • 2-Fluoro-4-chlorobenzyl chloride
  • 2-methyl-4-chlorobenzyl chloride
  • 3-trifluoromethyl-4-chlorobenzyl chloride
  • (4-Chlorobenzyl)(triphenyl)phosphonium chloride
  • (4-chlorobenzyl)-tri-(ethyl)-ammonium chloride
  • 3,4-Diethyl-1-methyl-1H-pyrazol-5-amine hydrate
  • 6-((3-(4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3-(4-methylbenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 3-(4-methylbenzyl)-6-((3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 6-((3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3-(4-methylbenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 6-((3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3-(4-methylbenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 6-((3-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-3-(4-methylbenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 3-(3-fluorobenzyl)-6-((3-(4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 3-(3-fluorobenzyl)-6-((3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 6-((3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3-(4-fluorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
  • 3-(4-fluorobenzyl)-6-((3-(4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.