4-Bromoanisole

Suppliers

Names

[ CAS No. ]:
104-92-7

[ Name ]:
4-Bromoanisole

[Synonym ]:
Benzene, 1-bromo-4-methoxy-
Of BroMoanisole
1-Bromo-4-methoxybenzene
Anisole, p-bromo-
p-Methoxyphenyl Bromide
p-anisylbromide
p-bromoanisol
Anisyl bromide
4-methoxyphenyl bromide
4-Bromoanisole
1-bromo-4-methoxy-benzene
4-BROMO ANISOL
4-methoxy-1-bromobenzene
p-Bromanisole
anisole, 4-bromo-
EINECS 203-252-1
4-Bromophenyl methyl ether
p-bromoanisole
MFCD00000097

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
223.0±0.0 °C at 760 mmHg

[ Melting Point ]:
9-10 °C(lit.)

[ Molecular Formula ]:
C₇H₇BrO

[ Molecular Weight ]:
187.034

[ Flash Point ]:
94.4±0.0 °C

[ Exact Mass ]:
185.968018

[ PSA ]:
9.23000

[ LogP ]:
3.16

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
immiscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8501000

CHEMICAL NAME :: Anisole, p-bromo-

CAS REGISTRY NUMBER :: 104-92-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H7-Br-O

MOLECULAR WEIGHT :: 187.05

WISWESSER LINE NOTATION :: ER DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(12),19,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1186 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(12),19,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81912 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 392 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
BZ8501000

[ Hazard Class ]:
6.1

[ HS Code ]:
29093038

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

p-Anisidine
Anisole
4-Methoxyphenylboronic acid
4-Bromophenol
Dimethyl sulfate
N,N-Dimethylformamide dimethyl acetal
4-Methoxybenzenediazonium tetrafluoroborate
4-Methoxyphenyl Trifluoromethanesulfonate
methyl iodide
1-Bromo-4-iodobenzene

DownStream

1-di(propan-2-yloxy)phosphoryl-4-methoxybenzene
2-Bromopropane
3,4-bis(4-methoxyphenyl)pyrrole-2,5-dione
3-(4-methoxyphenyl)-1-methylpyrrolidin-2-one
3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone
3-(4-methoxyphenoxy)aniline
4-[2-bis(4-hydroxyphenyl)phosphanylethyl-(4-hydroxyphenyl)phosphanyl]phenol
2-(4-Methoxyphenyl)pyrazine
5-(4-METHOXYPHENYL)-[2,2']BITHIOPHENYL
3-methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethyl]benzene-1,2-diol

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Contributions of BrCl, Br2, BrOCl, Br2O, and HOBr to regiospecific bromination rates of anisole and bromoanisoles in aqueous solution.

Environ. Sci. Technol. 49(8) , 4937-45, (2015)

When bromide-containing waters are chlorinated, conventional wisdom typically assumes HOBr is the only active brominating agent. Several additional and often-overlooked brominating agents (including B...

Hypobromous acid, a powerful endogenous electrophile: Experimental and theoretical studies.

J. Inorg. Biochem. 146 , 61-8, (2015)

Hypobromous acid (HOBr) is an inorganic acid produced by the oxidation of the bromide anion (Br(-)). The blood plasma level of Br(-) is more than 1,000-fold lower than that of chloride anion (Cl(-)). ...

Pd-catalyzed carbonylative α-arylation of aryl bromides: scope and mechanistic studies.

Chemistry 19(52) , 17926-38, (2013)

Reaction conditions for the three-component synthesis of aryl 1,3-diketones are reported applying the palladium-catalyzed carbonylative α-arylation of ketones with aryl bromides. The optimal condition...