p-Anisidine

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Names

[ CAS No. ]:
104-94-9

[ Name ]:
p-Anisidine

[Synonym ]:
p-ansidine
para-methoxyaniline
p-Methoxyphenylamine
4-Methoxyaniline
4-Methoxybenzenamine
4-Aminoanisole
4-Methoxy-phenylamine
1-Amino-4-methoxybenzene
Anisidine
aniline, 4-methoxy-
MFCD00007864
p-Aminoanisole
4-Anisidine
P-Anisidine
p-methoxyaniline
EINECS 203-254-2
4-Methoxy-benzenamine
Benzenamine, 4-methoxy-
PARA-ANISIDINE

Chemical & Physical Properties

[ Density]:
1.06

[ Boiling Point ]:
240-243 ºC

[ Melting Point ]:
56-59 °C(lit.)

[ Molecular Formula ]:
C₇H₉NO

[ Molecular Weight ]:
123.152

[ Flash Point ]:
122 ºC

[ Exact Mass ]:
123.068413

[ PSA ]:
35.25000

[ LogP ]:
0.74

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.555

[ Water Solubility ]:
21 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ5450000

CHEMICAL NAME :: p-Anisidine

CAS REGISTRY NUMBER :: 104-94-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 43

MOLECULAR FORMULA :: C7-H9-N-O

MOLECULAR WEIGHT :: 123.17

WISWESSER LINE NOTATION :: ZR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 806 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - normocytic anemia Blood - other changes

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.5 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,63,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 ppm (0.5 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,10,1973 OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-INDIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.5 mg/m3);STEL 0.2 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO p-ANISIDINE-air:10H TWA 0.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H310-H330-H350-H373-H400

[ Precautionary Statements ]:
P201-P260-P273-P280-P284-P301 + P310

[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;

[ Risk Phrases ]:
R26/27/28;R33;R45;R50

[ Safety Phrases ]:
S53-S28-S36/37-S45-S61-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
BZ5450000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29222200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Bromoanisole
4-Nitroanisole
1-Chloro-4-methoxybenzene
4,4-Azodianisole
4-Iodoanisole
4-Methoxyphenyl Trifluoromethanesulfonate
4'-Methoxyacetanilide
4-Methoxyphenylboronic Acid Pinacol Ester
2-(4-methoxyphenoxy)propanamide
carbon monoxide

DownStream

6-methoxy-1,3-benzoselenazol-2-amine
4-(6-METHOXYBENZO[D]THIAZOL-2-YL)-N,N-DIMETHYLANILINE
(1Z)-1-[(4-methoxyphenyl)imino]-1H-isoindol-3-amine
6-methoxy-2-phenyl-1,3-benzothiazole
4-chloro-N-[(4-methoxyphenyl)carbamothioyl]benzamide
3-PYRROLIDINECARBOXYLIC ACID, 1-(4-METHOXYPHENYL)-2-OXO-
3-(4-methoxyphenyl)-2-phenyl-1,3-thiazolidin-4-one
(4-methoxyphenyl)imino-triphenyl-λ5-arsane
1,3-Dioxane-4,5,6-trione, 2,2-dimethyl-, 5-[(4-methoxyphenyl)hydrazone] (en)
1-(4-methoxyphenyl)-7,7-dimethyl-3-[(3-nitrophenyl)methyl]-6,8-dihydroquinoline-2,5-dione

Customs

[ HS Code ]: 2922291000

[ Summary ]:
2922291000 4-methoxyaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

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