N,O-Bis(trimethylsilyl)acetamide

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Names

[ CAS No. ]:
10416-59-8

[ Name ]:
N,O-Bis(trimethylsilyl)acetamide

[Synonym ]:
TMS-BABSA
bsa kit
EINECS 233-892-7
tms-ba kit
MFCD00008270
N,O-Bis(trimethylsilyl)acetamide
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester, (1E)-
TMS-BA
Trimethylsilyl N-(trime
TMS-BA KitBSA Kit
CB2500
Trimethylsilyl (1E)-N-(trimethylsilyl)ethanimidoate
bis-TMS-acetamide
BSA
dynasylan bsa
Trimethylsilyl (1E)-N-(trimethylsilyl)ethanimidate
(E)-Trimethylsilyl N-(trimethylsilyl)acetimidate
Trimethylsilyl N-(trimethylsilyl)acetimidate

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
162.1±0.0 °C at 760 mmHg

[ Melting Point ]:
24 °C

[ Molecular Formula ]:
C8H21NOSi2

[ Molecular Weight ]:
203.429

[ Flash Point ]:
65.5±22.6 °C

[ Exact Mass ]:
203.116165

[ PSA ]:
21.59000

[ LogP ]:
3.16

[ Vapour Pressure ]:
2.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.411

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK3000000
CHEMICAL NAME :
Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
CAS REGISTRY NUMBER :
10416-59-8
LAST UPDATED :
199707
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H21-N-O-Si2
MOLECULAR WEIGHT :
203.48
WISWESSER LINE NOTATION :
1-SI-1&1&OY1&UN-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
REFERENCE :
StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,495,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7061 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 226 (estimated) No. of Female Employees: 151 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H314

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R10;R14;R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S7/8-S43A-S36-S30

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
AK3000000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
29310095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(Trimethylsilyl)imidazole
  • N-(Trimethylsilyl)acetamide
  • Acetamide
  • Chlorotrimethylsilane
  • n-sulfinylacetamide
  • Phenylthiotrimethylsilane

DownStream

  • 5-fluoro-N-trimethylsilyl-2-trimethylsilyloxypyrimidin-4-amine
  • bis(trimethylsilyl)bisphenol a
  • N-[(4-methylphenyl)carbamothioyl]acetamide
  • N-Benzyl-N,α,α,α-tetramethylsilanamine
  • 2-Phenyl-2-(trimethylsilyloxy)propane
  • 1-(Trimethylsilyl)-1H-benzotriazole
  • Trimethylsilanyl-(2-trimethylsilanyloxy-pyrimidin-4-yl)-amine
  • 4-[(TRIMETHYLSILYL)OXY]-BENZOIC ACID TRIMETHYLSILYL ESTER
  • trimethyl-(2-methylcyclohexen-1-yl)oxysilane

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • N,O-bis(trimethylsilyl)acetamide
  • N,O-Bis(trimethylsilyl)acetamide
  • N,O-bis(trimethylsilyl)acetamide
  • n,o-bis(trimethylsilyl)carbamate
  • N,O-Bis-(trimethylsilyl)-sarcosin
  • N,O-bis(trimethylsilyl)-D,L-homocysteic acid triethylammonium salt
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • ({3,5-Dimethyl-4-[(3-methylphenyl)methoxy]phenyl}methyl)(methyl)amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(5-allyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-7-yl)-2,4-dichlorobenzamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • N-(3-chloro-4-methoxyphenyl)-2-(6-cyclopropyl-5,7-dioxo-6,7-dihydroisothiazolo[4,3-d]pyrimidin-4(5H)-yl)acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde