DIPHENYL(QUINUCLIDIN-3-YL)METHANOL HYDROCHLORIDE
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Names
[ CAS No. ]:
10447-38-8
[ Name ]:
DIPHENYL(QUINUCLIDIN-3-YL)METHANOL HYDROCHLORIDE
[Synonym ]:
1-azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol,hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
430.2ºC at 760 mmHg
[ Molecular Formula ]:
C20H24ClNO
[ Molecular Weight ]:
329.86400
[ Flash Point ]:
208ºC
[ Exact Mass ]:
329.15500
[ PSA ]:
23.47000
[ LogP ]:
4.00420
[ Vapour Pressure ]:
3.65E-08mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VD4830000
- CHEMICAL NAME :
- 3-Quinuclidinemethanol, alpha,alpha-diphenyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 10447-38-8
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H23-N-O.Cl-H
- MOLECULAR WEIGHT :
- 329.90
- WISWESSER LINE NOTATION :
- T66 A B CNTJ AXQR&R &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 370 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 62 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 860 mg/kg
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - bronchiolar dilation Immunological Including Allergic - increased immune response
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,148,1980
Safety Information
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%