Caffeic acid phenethyl ester

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Names

[ Name ]:
Caffeic acid phenethyl ester

[Synonym ]:
Phenethyl 3-(3,4-dihydroxyphenyl)acrylate
Phenylethyl caffeate
Phenethyl caffeate
2-Phenyethyl caffeate
2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate
CAPE
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester, (E)-
Phenethyl 3,4-Dihydroxycinnamate
MFCD00866470
2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Caffeic acid phenethyl ester
3,4-Dihydroxycinnamic Acid Phenethyl Ester
Caffeic acid 2-phenylethyl ester
Caffeic Acid phenylethyl ester
2-Phenylethyl caffeate
2-Phenylethyl caffeoate
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester, (2E)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
498.6±45.0 °C at 760 mmHg

[ Melting Point ]:
129 °C

[ Molecular Formula ]:
C₁₇H₁₆O₄

[ Molecular Weight ]:
284.306

[ Flash Point ]:
185.1±22.2 °C

[ Exact Mass ]:
284.104858

[ PSA ]:
66.76000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.646

[ Storage condition ]:
Store at 0°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UD3334375

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(E)-4-(3-oxo-3-phenethoxyprop-1-enyl)-1,2-phenylene diacetate
Phenethyl alcohol
Caffeic acid
3,4-Dihydroxybenzaldehyde
malonic acid monophenethyl ester
(2-Bromoethyl)benzene
3,4-dihydroxycinnamic acid chloride
bis(2-phenylethyl) propanedioate
(E)-Caffeic Acid Diacetate

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Ganglioside GM3 is required for caffeic acid phenethyl ester-induced megakaryocytic differentiation of human chronic myelogenous leukemia K562 cells.

Biochem. Cell Biol. 92(4) , 243-9, (2014)

The human chronic myelogenous cell line K562 has been used extensively as a model for the study of leukemia differentiation. We show here that treatment of K562 cells with caffeic acid phenethyl ester...

Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.

Br. J. Pharmacol. 172(1) , 24-37, (2014)

N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic (DHA; 22: 6n-3). Its concentration in animal tissues and human plasm...

Effects of caffeic acid phenethyl ester on wound healing in calvarial defects.

Acta Odontol. Scand. 73(1) , 21-7, (2014)

The aim of this study is to analyze histologically the effect of CAPE on bone healing of Critical Size Defect (CSD) in rat calvaria.Thirty-two 3-month-old male rats were used. The animals were randoml...