Pramipexole dihydrochloride

Suppliers

Names

[ Name ]:
Pramipexole dihydrochloride

[Synonym ]:
2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride (1:2)
(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Pramipexole hydrochloride
Pramipexole dihydrochloride
MFCD00876894
(S)-Pramipexole Dihydrochloride
(6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride
(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
Pramipexole (dihydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
378ºC at 760 mmHg

[ Melting Point ]:
288-290ºC

[ Molecular Formula ]:
C₁₀H₁₉Cl₂N₃S

[ Molecular Weight ]:
284.249

[ Flash Point ]:
182.4ºC

[ Exact Mass ]:
283.067688

[ PSA ]:
79.18000

[ LogP ]:
4.15830

[ Vapour Pressure ]:
6.49E-06mmHg at 25°C

[ Storage condition ]:
Desiccate at RT

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(6S)-2-Amino-6-propionamidotetrahydrobenzothiazole
Pramipexole
rac-cis-7-Hydroxy Pramipexole
4,5,6,7-TETRAHYDRO-2,6-BENZOTHIAZOLE DIAMINE
N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide Hydrobromide
N-(4-Oxocyclohexyl)acetamide
(S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
(S)-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine tartrate trihydrate

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.

Pharmacol. Biochem. Behav. 131 , 1-5, (2015)

Pramipexole is widely prescribed for the treatment of Parkinson's disease. This dopamine (DA) receptor agonist has a higher affinity for D3 over D2 receptors. We compared the effect of pramipexole to ...

Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

PLoS ONE 10(3) , e0117698, (2015)

Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour whic...

De novo expression of dopamine D2 receptors on microglia after stroke.

J. Cereb. Blood Flow Metab. 35 , 1804-11, (2015)

Dopamine is the predominant catecholamine in the brain and functions as a neurotransmitter. Dopamine is also a potent immune modulator. In this study, we have characterized the expression of dopamine ...

Pramipexole dihydrochloride
DEXPRAMIPEXOLE DIHYDROCHLORIDE
(R)-Pramipexole Dihydrochloride
(+)-Pramipexole dihydrochloride
PRAMIPEXOLE DIHYDROCHLORIDE ANHYDROUS
Pramipexole dihydrochloride impurity,N-propylpramipexole-[USP]
3-ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]azetidine-3-carboxylic acid
3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[(3-methanesulfonyl-2,2-dimethylpropyl)carbamoyl]propanoic acid
3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(1R,5S)-8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl]-4-oxobutanoic acid
1-[1-(2,4-dimethyl-1H-pyrrol-3-yl)cyclopropyl]cyclopropan-1-amine
3-{[(3,5-dimethylpyridin-2-yl)methyl]carbamoyl}-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
4-[(4-bromophenyl)(methyl)carbamoyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
rac-[(1R,3R)-3-(6-fluoropyridin-3-yl)-2,2-dimethylcyclopropyl]methanamine
2-(2-Methyloxolan-3-yl)cyclopropan-1-amine
3-[(1S)-3-amino-1-hydroxypropyl]benzene-1,2-diol
3-{[2-(1-benzylpyrrolidin-3-yl)ethyl]carbamoyl}-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

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