Pramipexole dihydrochloride

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Names

[ CAS No. ]:
104632-25-9

[ Name ]:
Pramipexole dihydrochloride

[Synonym ]:
2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride (1:2)
(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Pramipexole hydrochloride
Pramipexole dihydrochloride
MFCD00876894
(S)-Pramipexole Dihydrochloride
(6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride
(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
Pramipexole (dihydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
378ºC at 760 mmHg

[ Melting Point ]:
288-290ºC

[ Molecular Formula ]:
C10H19Cl2N3S

[ Molecular Weight ]:
284.249

[ Flash Point ]:
182.4ºC

[ Exact Mass ]:
283.067688

[ PSA ]:
79.18000

[ LogP ]:
4.15830

[ Vapour Pressure ]:
6.49E-06mmHg at 25°C

[ Storage condition ]:
Desiccate at RT

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (6S)-2-Amino-6-propionamidotetrahydrobenzothiazole
  • Pramipexole
  • rac-cis-7-Hydroxy Pramipexole
  • 4,5,6,7-TETRAHYDRO-2,6-BENZOTHIAZOLE DIAMINE
  • N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide Hydrobromide
  • N-(4-Oxocyclohexyl)acetamide
  • (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
  • (S)-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine tartrate trihydrate

DownStream

  • Pramipexole

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.

Pharmacol. Biochem. Behav. 131 , 1-5, (2015)

Pramipexole is widely prescribed for the treatment of Parkinson's disease. This dopamine (DA) receptor agonist has a higher affinity for D3 over D2 receptors. We compared the effect of pramipexole to ...

Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

PLoS ONE 10(3) , e0117698, (2015)

Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour whic...

De novo expression of dopamine D2 receptors on microglia after stroke.

J. Cereb. Blood Flow Metab. 35 , 1804-11, (2015)

Dopamine is the predominant catecholamine in the brain and functions as a neurotransmitter. Dopamine is also a potent immune modulator. In this study, we have characterized the expression of dopamine ...


More Articles

Related Compounds

  • Pramipexole dihydrochloride
  • DEXPRAMIPEXOLE DIHYDROCHLORIDE
  • (R)-Pramipexole Dihydrochloride
  • (+)-Pramipexole dihydrochloride
  • PRAMIPEXOLE DIHYDROCHLORIDE ANHYDROUS
  • Pramipexole dihydrochloride impurity,N-propylpramipexole-[USP]
  • 6-[1-(aminomethyl)-3,3-difluorocyclobutyl]-2,3-difluoro-N,N-dimethylaniline
  • tert-butyl N-[3-(1-aminocyclohexyl)-4-methoxyphenyl]carbamate
  • 3-Fluoro-3-(5-phenylthiophen-2-yl)propan-1-amine
  • 1-[3-(Methoxymethyl)furan-2-yl]-3-oxocyclobutane-1-carboxylic acid
  • 2,2-Dimethyl-1-[3-(trifluoromethoxy)phenyl]cyclopropan-1-amine
  • 3-(4-Methylpyrimidin-5-yl)-2-oxopropanoic acid
  • 4-[5-(Azetidin-3-yl)-1,3-thiazol-2-yl]morpholine
  • 1-amino-2-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]propan-2-ol
  • 1-[2-(3-Methylfuran-2-yl)propan-2-yl]cyclopropan-1-amine
  • 1-methyl-5-(2-methyl-2,3-dihydro-1-benzofuran-5-yl)-1H-pyrazol-4-amine
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