Clodronic Acid
Suppliers
Names
[ CAS No. ]:
10596-23-3
[ Name ]:
Clodronic Acid
[Synonym ]:
Clodronic Acid
methanedichlorodiphosphonic acid
Acide clodronique
Acidum clodronicum
Bonefos
Acido clodronico
Clodronsaeure
Dichloromethylidene diphosphonate
(dichloromethylene)bisphosphonic acid
[dichloro(phosphono)methyl]phosphonic acid
Dichloromethanediphosphonic acid
EINECS 234-212-1
dichloromethanediphosphonate
dichloro-methylene diphosphonate
(dichloromethanediyl)bis(phosphonic acid)
(Dichloromethylene)bis(phosphonic acid)
Phosphonic acid, (dichloromethylene)bis-
P,P'-(Dichloromethylene)Bis-Phosphonic Acid
Clodronate
dichloromethylenediphosphonic acid
Clodronate disodium
Chemical & Physical Properties
[ Density]:
2.3±0.1 g/cm3
[ Boiling Point ]:
474.7±55.0 °C at 760 mmHg
[ Melting Point ]:
249-251°
[ Molecular Formula ]:
CH4Cl2O6P2
[ Molecular Weight ]:
244.892
[ Flash Point ]:
240.9±31.5 °C
[ Exact Mass ]:
243.886017
[ PSA ]:
134.68000
[ LogP ]:
-2.38
[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C
[ Index of Refraction ]:
1.598
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ7640500
- CHEMICAL NAME :
- Phosphonic acid, (dichloromethylene)bis-
- CAS REGISTRY NUMBER :
- 10596-23-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C-H4-Cl2-O6-P2
- MOLECULAR WEIGHT :
- 244.89
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg/4D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,365,1987
Safety Information
[ HS Code ]:
2931900090
Customs
[ HS Code ]: 2931900090
[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%