12-hydroxyoctadecanoic acid

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Names

[ CAS No. ]:
106-14-9

[ Name ]:
12-hydroxyoctadecanoic acid

[Synonym ]:
MFCD00004592
DL-12-hydroxystearic acid
Octadecanoic acid, 12-hydroxy-
EINECS 203-366-1
UNII:933ANU3H2S
12-Hydroxyoctadecanoic acid
DL-12-hydroxy stearic acid
12-Hydroxystearic acid

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
436.3±18.0 °C at 760 mmHg

[ Melting Point ]:
80-81ºC

[ Molecular Formula ]:
C18H36O3

[ Molecular Weight ]:
300.477

[ Flash Point ]:
231.8±17.7 °C

[ Exact Mass ]:
300.266449

[ PSA ]:
57.53000

[ LogP ]:
6.03

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.468

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WI3850000
CHEMICAL NAME :
Stearic acid, 12-hydroxy-
CAS REGISTRY NUMBER :
106-14-9
BEILSTEIN REFERENCE NO. :
1726730
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H36-O3
MOLECULAR WEIGHT :
300.54
WISWESSER LINE NOTATION :
QV10YQ6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
700 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,87,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1187 No. of Facilities: 5682 (estimated) No. of Industries: 85 No. of Occupations: 50 No. of Employees: 71848 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1187 No. of Facilities: 5607 (estimated) No. of Industries: 44 No. of Occupations: 38 No. of Employees: 52609 (estimated) No. of Female Employees: 4374 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
WI3850000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Octadecanoic acid,12-oxo-
  • (R)-12-Hydroxystearic acid methyl ester
  • 12-hydroxystearic acid ethyl ester
  • methyl ricinoleate
  • ricinoleic acid
  • 11-CYANO-1-UNDECANOIC ACID
  • Hexylmagnesium chloride solution
  • 12-oxo-octadecanenitrile
  • Monoethyl Dodecanedioate

DownStream

  • Octadecanamide,12-hydroxy-N-(2-hydroxyethyl)-
  • trans-11-octadecenoic acid
  • 13,26-dihexyl-1,14-dioxacyclohexacosane-2,15-dione
  • 12-hydroxystearic acid lactone
  • 2-ethylhexyl 12-hydroxyoctadecanoate
  • n-heptanoic acid
  • Undecanedioic acid
  • Dodecanedioic acid
  • 1-Hexanoic acid
  • Azelaic acid

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion.

Int. J. Pharm. 486 , 77-87, (2015)

The aim of this work is to study the digestibility of PEG-30-di-(polyhydroxystearate) (Cithrol(®) DPHS) and its semisolid novel self-nanoemulsifying drug delivery systems (SNEDDS). Furthermore, the SN...

Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma.

Int. J. Pharm. 495 , 972-80, (2015)

In this work, multifunctional lipid nanocapsules (M-LNC) were designed to combine the activity of the cytotoxic drug paclitaxel (PTX) with the immunostimulant CpG. This nanosystem, consisting of modif...

Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect.

Int. J. Pharm. 484(1-2) , 163-71, (2015)

The present paper attempted to develop temperature-sensitive and core-shell structured gel-nanocarriers (gel-NCs) for paclitaxel (PTX) with 12-hydroxystearic acid (12-HSA) as an organic gelator, which...


More Articles

Related Compounds

  • 12-Hydroxyoctadecanoic acid
  • 12-Hydroxyoctadecanoic acid
  • 12-Hydroxyoctadecanoic acid
  • 12-Hydroxyoctadecanoic acid
  • 12-Hydroxyoctadecanoic acid
  • D-12-Hydroxyoctadecanoic acid
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