4-Bromoaniline

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Names

[ CAS No. ]:
106-40-1

[ Name ]:
4-Bromoaniline

[Synonym ]:
para bromo aniline
para-bromoaniline
Benzenamine,4-bromo
4-bromo-aniline
4-bromobenzenamide
4-Bromoaniline
EINECS 203-393-9
4-Bromobenzenamine
ZR DE
MFCD00007822
P-BROMOANILINE
Aniline,p-bromo
Benzenamine, 4-bromo-
p-Bromophenylamine
1-amino-4-bromobenzene
4-bromo-phenylamine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
225.9±13.0 °C at 760 mmHg

[ Melting Point ]:
56-62 °C(lit.)

[ Molecular Formula ]:
C₆H₆BrN

[ Molecular Weight ]:
172.023

[ Flash Point ]:
90.4±19.8 °C

[ Exact Mass ]:
170.968353

[ PSA ]:
26.02000

[ LogP ]:
2.05

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, peroxides, acids, acid chlorides, acid anhydrides, chloroformates. May be air sensitive.

[ Water Solubility ]:
<0.1 g/100 mL at 23 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BW9280000

CHEMICAL NAME :: Aniline, p-bromo-

CAS REGISTRY NUMBER :: 106-40-1

BEILSTEIN REFERENCE NO. :: 0742031

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H6-Br-N

MOLECULAR WEIGHT :: 172.04

WISWESSER LINE NOTATION :: ZR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 456 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 289 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 248 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 50 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2753 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2753 No. of Facilities: 184 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 4703 (estimated) No. of Female Employees: 3745 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H311-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P312

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37-S36/37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BW9280000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29214210

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Bromo-4-iodobenzene
4-Bromophenylboronic Acid
1,4-Dibromobenzene
2-(4-bromophenoxy)propanamide
1-Bromo-4-nitrobenzene
Potassium (4-bromophenyl)(trifluoro)borate(1-)
Acetamide, N-(4-bromophenyl)-2,2,2-trifluoro-
4-bromo-N-hydroxybenzamide
4-Bromoacetanilide

DownStream

6-[(4-bromoanilino)methylidene]-4-methylcyclohexa-2,4-dien-1-one
4-Thiazolidinone,3-(4-bromophenyl)-2-thioxo-
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,4-thiazinane 1,1-dioxide
2-(1-((4-BROMOPHENYL)IMINO)ETHYL)-4-CHLOROPHENOL
6-bromo-4-chloroquinoline (Hydrochloride)
N-(4-Bromophenyl)-2-methoxyacetamide
3-(4-bromoanilino)-5,5-dimethylcyclohex-2-en-1-one
4-(1,1-DIOXOTHIOMORPHOLINO)PHENYL BROMIDE
1-(8-bromo-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethanone
N-(4-bromophenyl)hydroxylamine

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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