SERTINDOLE

Suppliers

Names

[ Name ]:
SERTINDOLE

[Synonym ]:
1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
1-(2-{4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl}ethyl)-2-imidazolidinone
1-[2-[4-[5-chloro-1-(p-fluorophenyl)indol-3-yl]piperidino]ethyl]-2-imidazolidinone
1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
2-Imidazolidinone, 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-
2-Imidazolidinone, 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]
1-(2-{4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
MFCD00867749
Sertindole

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
592.1±50.0 °C at 760 mmHg

[ Melting Point ]:
95-100ºC

[ Molecular Formula ]:
C₂₄H₂₆ClFN₄O

[ Molecular Weight ]:
440.941

[ Flash Point ]:
311.9±30.1 °C

[ Exact Mass ]:
440.177917

[ PSA ]:
40.51000

[ LogP ]:
5.26

[ Appearance of Characters ]:
off-white

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.671

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >10mg/mL

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NJ0621100

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-(2-Chlorethyl)imidazolidin-2-on
5-Chloro-1-(4-fluorophenyl)-3-(piperidin-4-yl)-1H-indole
4-Oxopiperidinium chloride
5-Chloro-1-(4-fluorophenyl)indole
methyl 5-chloro-1-(4-fluorophenyl)-3-hydroxy-1H-indol-2-carboxylate
5-Chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

DownStream

Articles

An investigation of the stability of emerging new psychoactive substances.

Drug Test. Anal. 6(7-8) , 696-704, (2014)

The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detec...

Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices.

Eur. J. Neurosci. 36(12) , 3628-35, (2012)

Agents such as sertindole and astemizole affect heart action by inducing long-QT syndrome, suggesting that apart from their neuronal actions through histamine receptors, 5-HT2 serotonin receptors and ...

Risperidone versus other atypical antipsychotics for schizophrenia.

Cochrane Database Syst. Rev. (1) , CD006626, (2011)

In many countries of the industrialised world second-generation ("atypical") antipsychotics (SGAs) have become the first line drug treatment for people with schizophrenia. The question as to whether a...

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