Tafenoquine (Succinate)

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Names

[ CAS No. ]:
106635-81-8

[ Name ]:
Tafenoquine (Succinate)

[Synonym ]:
Tafenoquine succinate
UNII-DL5J0B8VSS
Tafenoquine Succinate
tafenoquine maleate
Etaquine
Tafenoquine (Succinate)

Chemical & Physical Properties

[ Density]:
1.237g/cm3

[ Boiling Point ]:
565.6ºC at 760mmHg

[ Molecular Formula ]:
C28H34F3N3O7

[ Molecular Weight ]:
581.58100

[ Flash Point ]:
295.9ºC

[ Exact Mass ]:
581.23500

[ PSA ]:
153.23000

[ LogP ]:
6.61990

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SA0242400
CAS REGISTRY NUMBER :
106635-81-8
LAST UPDATED :
199107
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C24-H28-F3-N3-O3.C4-H6-O4
MOLECULAR WEIGHT :
581.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
416 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 32,1728,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 32,1728,1989

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania.

J. Antimicrob. Chemother. 66(11) , 2562-5, (2011)

The present study was designed to elucidate the mechanism of tafenoquine uptake in Leishmania and its sterol dependence.Because tafenoquine is a fluorescent compound, spectrofluorimetric analysis allo...

Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.

Am. J. Trop. Med. Hyg. 69(5) , 542-7, (2003)

The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of Plasmodium vivax in western Thailand. Primaquine was used as a negativ...

Military aviators, special operations forces, and causal malaria prophylaxis.

Mil. Med. 168(12) , 1001-6, (2003)

U.S. military aviators are currently restricted to the use of chloroquine or doxycycline for malaria prophylaxis. Ground forces are allowed the additional option of taking mefloquine. These medication...


More Articles

Related Compounds

  • Tafenoquine succinate
  • Tafenoquine
  • Hydrocortisone succinate
  • Octahydroaminoacridine succinate
  • Levamfetamine succinate
  • lithium succinate
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  • 6-methoxy-N-[4-(trifluoromethoxy)phenyl]pyridazine-3-carboxamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
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  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • PU-H71 hydrate