Diethyl acetamidomalonate

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Names

[ Name ]:
Diethyl acetamidomalonate

[Synonym ]:
DIETHYL (ACETYLAMINO)MALONATE
DIETHYL ACEAMIDOMALONATE
Diethyl2-acetamidomalonate
DIETHYLACETAMIDO MALONATE
2-ACETYLAMINO-MALONIC ACID DIETHYL ESTER AA-DEM ACETAMIDO DIETHYL MALONATE ACETAMIDOMALONIC ACID DIETHYL ESTER
DIETHYL ACETAMIDO MALONATE
Diethyl 2-acetamidomalonate
EINECS 213-952-9
Polyacrylic resin Ⅲ
Acetaminomalonic acid diethyl ester
ACETAMINOPROPANDIOIC ACID DIETHYL ESTER
DIETHYL ACETAMIDOMALONATE FOR SYNTHESIS
2-ACETYLAMINOMALONIC ACID DIETHYL ESTER
Propanedioic acid, 2-[[(1E)-1-hydroxyethylidene]amino]-, diethyl ester
ALPHA-ACETAMIO MALONIC ACID DIETHYL ESTER
(1E)-N-(1,3-Diethoxy-1,3-dioxo-2-propanyl)ethanimidic acid
Diethyl-(acetylamino)propandioat
(S)-3-(1-amino-2,2,2-trifluoroethyl)aniline hydrochloride
2-((4-CHLOROPHENYL)SULFONYL)-3-((4-(TRIFLUOROMETHYL)(2-PYRIDYL))
Propanedioic acid, 2-(acetylamino)-, diethyl ester
2-ACETYLAMINO-MALONIC ACID DIETHYL ESTER
Ethyl Acetamidomalonate
Diethylacetamidomalonate
DIETHYL ACETAMINOMALONATE
Acetamidomalonic Acid Diethyl Ester
PROPANEDIOICACID,(ACETYLAMINO)-,DIETHYLESTER
diethyl 2-(acetylamino)malonate
diethyl 2-acetamidopropanedioate
ACETAMIDO DIETHYL MALONATE
Diethyl acetamidomalonate
MFCD00009146

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
311.4±0.0 °C at 760 mmHg

[ Melting Point ]:
95-98 °C(lit.)

[ Molecular Formula ]:
C₉H₁₅NO₅

[ Molecular Weight ]:
217.22

[ Flash Point ]:
145.2±22.3 °C

[ Exact Mass ]:
217.095016

[ PSA ]:
81.70000

[ LogP ]:
0.36

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.447

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO0360000

CHEMICAL NAME :: Malonic acid, acetamido-, diethyl ester

CAS REGISTRY NUMBER :: 1068-90-2

BEILSTEIN REFERENCE NO. :: 0783883

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H15-N-O5

MOLECULAR WEIGHT :: 217.25

WISWESSER LINE NOTATION :: 2OVYVO2&MV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,742,1986

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OO0360000

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DIETHYL ISONITROSOMALONATE
Aminomalonamid
Acetyl chloride
Ethanoic anhydride
Diethyl malonate
Diethyl 2-aminomalonate
Triethyl orthoacetate
Diethyl nitromalonate
acetic acid
Propanedioic acid, 2-amino-, 1-ethyl ester

DownStream

DIETHYL 2-ACETAMIDO-2-ETHYLMALONATE
α-Aminoadipic acid
Ethyl Acetamidomalonate
5-Methyl-1H-pyrrole-2-carboxylic acid
Diethyl acetamido(2-phenylethyl)malonate
Ethyl 5-methyl-1H-pyrrole-2-carboxylate
α-Acetamino-α-carboxy-(3-indole)-butyric Acid
Ac-Gly-OH
2-acetamido-3-(4-cyanophenyl)propanoic acid
Glutamic acid,4-methyl-

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

A modified, high yield procedure for the synthesis of unlabeled and 14C-labeled 4-methylene-DL-glutamic acid.

Prep. Biochem. 11(3) , 339-50, (1981)

This paper describes the complete chemical synthesis of 4-methylene-DL-glutamic acid from diethylmalonate, formaldehyde and diethyl acetamidomalonate. The amino acid was obtained pure following ion-ex...

Synthesis of ribo-hexopyranoside- and altrose-based azacrown ethers and their application in an asymmetric Michael addition.

Carbohydr. Res. 365 , 61-8, (2013)

The synthesis of four new ribo-hexopyranoside-based chiral lariat ethers of monoaza-15-crown-5 type and two altropyranoside-based crown ethers were elaborated. Our syntheses utilized the regioselectiv...

A new approach to 3-substituted tetrahydro-β-carboline derivative via diethyl acetamidomalonate.

Amino Acids 41(4) , 933-6, (2011)

Strategically a new approach for the synthesis tetrahydro-β-carboline unit with the aid of diethyl acetamidomalonate as a glycine equivalent has been described.