Loperamide

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Names

[ CAS No. ]:
106900-12-3

[ Name ]:
Loperamide

[Synonym ]:
Loperamide N-oxide
Loperamide oxide
trans-N-Oxide of loperamide
Arestal

Chemical & Physical Properties

[ Molecular Formula ]:
C29H33ClN2O3

[ Molecular Weight ]:
493.03700

[ Exact Mass ]:
492.21800

[ PSA ]:
69.97000

[ LogP ]:
5.05940

[ Water Solubility ]:
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM4960200
CHEMICAL NAME :
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha -diphenyl-, 1-oxide, (E)-
CAS REGISTRY NUMBER :
106900-12-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C29-H33-Cl-N2-O3
MOLECULAR WEIGHT :
493.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
172 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

Safety Information

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
TM4960200

Related Compounds

  • Loperamide
  • Loperamide-d6
  • LOPERAMIDE-D6
  • LOPERAMIDE HCL
  • Loperamide phenyl
  • Dehydro Loperamide
  • 2-(2-Amino-3,3-difluoro-2-methylpropyl)-4-chlorophenol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 3-[5-(4-Methylphenyl)furan-2-yl]propane-1-thiol
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine