Loperamide

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Names

[ CAS No. ]:
106900-12-3

[ Name ]:
Loperamide

[Synonym ]:
Loperamide N-oxide
Loperamide oxide
trans-N-Oxide of loperamide
Arestal

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₃ClN₂O₃

[ Molecular Weight ]:
493.03700

[ Exact Mass ]:
492.21800

[ PSA ]:
69.97000

[ LogP ]:
5.05940

[ Water Solubility ]:
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM4960200

CHEMICAL NAME :: 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha -diphenyl-, 1-oxide, (E)-

CAS REGISTRY NUMBER :: 106900-12-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H33-Cl-N2-O3

MOLECULAR WEIGHT :: 493.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 172 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

Safety Information

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
TM4960200

Related Compounds

Loperamide
Loperamide-d6
LOPERAMIDE-D6
LOPERAMIDE HCL
Loperamide phenyl
Dehydro Loperamide
[(2,3-Difluorophenyl)methyl](2-methylpropyl)amine
N-[(2,3-difluorophenyl)methyl]cyclopentanamine
N-[1-({2-methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}amino)-2-oxo-2-(thiophen-2-yl)ethyl]benzamide
N-[2-(4-methylphenyl)-2-oxo-1-({4-[(E)-phenyldiazenyl]phenyl}amino)ethyl]thiophene-2-carboxamide
2-{1-[(4-fluorophenoxy)acetyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}-N-(4-fluorophenyl)acetamide
1-(2,5-Dimethyl-1h-pyrrol-3-yl)-2-((1-methyl-1h-imidazol-2-yl)thio)ethan-1-one
Ethyl 2-((2-(2,5-dimethyl-1h-pyrrol-3-yl)-2-oxoethyl)thio)acetate
N-(3,4-dichlorophenyl)-2-[1-(furan-2-carbonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]acetamide
1-(1H-1,3-benzodiazol-2-yl)-3-hydroxy-4-(4-methylbenzoyl)-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one
1-[[4-(4-Chlorophenoxy)phenyl]methyl]azetidine-3-carboxylic acid

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