Crotonic acid

Suppliers

Names

[ CAS No. ]:
107-93-7

[ Name ]:
Crotonic acid

[Synonym ]:
Crotonic acid
(E)-But-2-enoic acid
MFCD00002701
α-Crotonic acid
2-Butenoic acid, (2E)-
(2E)-2-Butenoic acid
(2E)-But-2-enoic acid
trans-2-Butenoic acid
crotonate
EINECS 203-533-9
β-Methylacrylic acid

Chemical & Physical Properties

[ Density]:
1.027

[ Boiling Point ]:
185-199 ºC

[ Melting Point ]:
70-73ºC

[ Molecular Formula ]:
C₄H₆O₂

[ Molecular Weight ]:
86.089

[ Flash Point ]:
88 ºC

[ Exact Mass ]:
86.036781

[ PSA ]:
37.30000

[ LogP ]:
0.80

[ Vapour density ]:
2.97 (vs air)

[ Vapour Pressure ]:
0.5±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Water Solubility ]:
94 g/L (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ2900000

CHEMICAL NAME :: Crotonic acid, (E)-

CAS REGISTRY NUMBER :: 107-93-7

BEILSTEIN REFERENCE NO. :: 1719943

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H6-O2

MOLECULAR WEIGHT :: 86.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,75,1992

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38;R50/53

[ Safety Phrases ]:
S26-S37/39-S61

[ RIDADR ]:
UN 2823

[ WGK Germany ]:
3

[ RTECS ]:
GQ2900000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29161940

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methyl bromocrotonate
carbon monoxide
allyl triethylammonium bromide
2-buten-1-ol
Crotonaldehyde
2-methylprop-2-enyl but-2-enoate
2-propenyl-3-butenoate
trimethyl-(2-trimethylsilyl-1-trimethylsilyloxyethenoxy)silane
ch3cho

DownStream

2,3-dibromobutyric acid
TRIMETHYLSILYL 4-TRIMETHYLSILYLCROTONATE
3-Methylindanone
3-Phenylbutyric acid
6-chloro-2-methyl-2,3-dihydrothiochromen-4-one
3-(4-CHLOROPHENYLTHIO)BUTYRIC ACID
2,7-Dimethyl-2,3-dihydro-4H,5H-pyrano[4,3-b]pyran-4,5-dione
2-Butenamide,N,N-diethyl-, (2E)-
3-chlorobutanoyl chlrode
p-isopropenylanisole

Customs

[ HS Code ]: 29161940

Articles

Identification of the toxic trigger in mushroom poisoning.

Nat. Chem. Biol. 5 , 465-7, (2009)

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a...

Chemical renal medullectomy. Effect on urinary prostaglandin E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure.

Hypertension 5(6) , 951-7, (1983)

We have studied the possible vasodepressor role of the renal medulla by chemical medullectomy. Bromoethylamine hydrobromide (200 mg/kg) was injected to induce selective renal medullary necrosis in rat...

Using organic acids to control subacute ruminal acidosis and fermentation in feedlot cattle fed a high-grain diet.

J. Anim. Sci. 93 , 3950-8, (2015)

The objective of this study was to determine whether supplementing organic acids can prevent incidences of subacute ruminal acidosis (SARA) in beef heifers fed a diet consisting of 8% barley silage an...