4-Hydroxythioanisole

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Names

[ CAS No. ]:
1073-72-9

[ Name ]:
4-Hydroxythioanisole

[Synonym ]:
4-(Methylmercapto)phenol
4-Hydroxythioanisole
4-(Methylthio)phenol
4-methylsulfanylphenol
MFCD08443600
QR DS1
4-(Hydroxy)thioanisole
p-Hydroxythioanisole
p-(Methylthio)phenol
Phenol, 4-(methylthio)-
EINECS 214-031-4
Phenol, p-(methylthio)-
4-(Methylsulfanyl)phenol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
269.7±0.0 °C at 760 mmHg

[ Melting Point ]:
84-86(lit.)

[ Molecular Formula ]:
C7H8OS

[ Molecular Weight ]:
140.203

[ Flash Point ]:
127.7±21.3 °C

[ Exact Mass ]:
140.029587

[ PSA ]:
45.53000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.613

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SM1578500
CHEMICAL NAME :
Phenol, p-(methylthio)-
CAS REGISTRY NUMBER :
1073-72-9
BEILSTEIN REFERENCE NO. :
2041507
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C7-H8-O-S
MOLECULAR WEIGHT :
140.21
WISWESSER LINE NOTATION :
QR DS1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 8,302,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8480 ng/kg/12D-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 45,935,1982

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ RTECS ]:
SM1578500

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(Methylthio)phenylboronic acid
  • 4-Mercaptophenol
  • methyl iodide
  • 4-Iodophenol
  • Dimethyl sulfoxide
  • p-methylthioanisole
  • Phenol
  • Methanesulfenic acid chloride
  • 4-Iodophenyl methyl sulfide
  • 4-thiomethylphenyl allyl ester

DownStream

  • 4-HYDROXYPHENYLDIMETHYLSULFONIUM METHYL SULFATE
  • 3-[4-(METHYLTHIO)PHENOXY]PROPIONIC ACID
  • tris(4-methylsulfanylphenyl) phosphite
  • 2-hydroxy-5-(methylthio)benzaldehyde
  • Salicylaldehyde
  • Fexinidazole
  • Sulfonium,(4-hydroxyphenyl)dimethyl-, chloride (1:1)
  • 2-(Methylthio)phenol
  • 1-(4-methylsulfonylphenoxy)-4-nitrobenzene
  • 1-methylsulfanyl-4-prop-2-ynoxybenzene

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Bacterial reduction of fensulfothion and its hydrolysis product 4-methylsulfinyl phenol.

Appl. Environ. Microbiol. 49(1) , 236-7, (1985)

Oxygen-limited cultures of Klebsiella pneumoniae reduced 4-methylsulfinyl phenol to 4-methylthiophenol. A study of the effect of 4-methylthiophenol on the growth of K. pneumoniae revealed that the spe...

Transition-metal-free highly efficient aerobic oxidation of sulfides to sulfoxides under mild conditions.

Molecules 15(1) , 83-92, (2010)

A highly efficient transition-metal-free catalytic system Br2/NaNO2/H2O has been developed for a robust and economic acid-free aerobic oxidation of sulfides. It is noteworthy that the sulfide function...

Dimerization of ionized 4-(methyl mercapto)-phenol during ESI, APCI and APPI mass spectrometry.

J. Mass Spectrom. 44(9) , 1389-94, (2009)

A novel ion/molecule reaction was observed to occur under electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photo ionization (APPI) conditions, l...


More Articles

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