4-Nitropyridine 1-oxide

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Names

[ CAS No. ]:
1074-98-2

[ Name ]:
4-Nitropyridine 1-oxide

[Synonym ]:
3-methyl-4-nitropyridine-N-oxide
4-Nitro-3-picoline N-Oxide
4-Nitropyridine-N-oxide
4-Nitro-B-picoline N-oxide
3-methyl-4-nitro-pyridin1-oxide
3-methyl-4-nitropyridine-l-oxide
4-Nitropyridine-1-oxyde
EINECS 214-050-8
4-Nitro-3-picoline 1-oxide
3-Methyl-4-nitropyridine N-Oxide
MFCD00014626
3-Picoline,4-nitro-,1-oxide
4-Nitro-3-picoline-N-oxide
3-methyl-4-nitropyridine-1-oxide
3-Methyl-4-nitropyri
4-Nitropyridine 1-oxide
Pyridine, 4-nitro-, 1-oxide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
397.2±15.0 °C at 760 mmHg

[ Melting Point ]:
135-139 °C

[ Molecular Formula ]:
C6H6N2O3

[ Molecular Weight ]:
140.097

[ Flash Point ]:
194.0±20.4 °C

[ Exact Mass ]:
140.022186

[ PSA ]:
71.28000

[ LogP ]:
-0.55

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.601

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT5775000
CHEMICAL NAME :
Pyridine, 3-methyl-4-nitro-, 1-oxide
CAS REGISTRY NUMBER :
1074-98-2
BEILSTEIN REFERENCE NO. :
0140157
LAST UPDATED :
199612
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C6-H6-N2-O3
MOLECULAR WEIGHT :
154.14
WISWESSER LINE NOTATION :
T6NJ AO C1 DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1680 mg/kg/28W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1680 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - hamster Cells - not otherwise specified
DOSE/DURATION :
8 umol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 229,416,1971

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335-H351

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R40

[ Safety Phrases ]:
S45-S36/37-S36-S26-S22

[ RIDADR ]:
2811

[ RTECS ]:
UT5775000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-picoline n-oxide
  • 3-Mepy
  • Sulfuric acid
  • nitric acid

DownStream

  • 1-(benzenesulfonyl)-1H-pyrrolo[3,2-c]pyridine
  • 4-Aminonicotinaldehyde
  • N-(3-methylpyridin-4-yl)nitramide
  • 2-chloro-5-methylpyridine-3,4-diamine
  • 4-NITRO-3-FORMYLPYRIDINE-OXIDE
  • 4-Aminonicotinic acid
  • Pyridine,4-bromo-3-methyl-, 1-oxide
  • 3-[2-(Dimethylamino)vinyl]-4-nitropyridine 1-Oxide
  • 4-Bromo-3-methylpyridine
  • 4-Chloro-3-methylpyridine-N-oxide

Related Compounds

  • 4-Nitropyridine 1-oxide
  • 4-Nitropyridine 1-oxide
  • 2-Bromo-4-nitropyridine 1-oxide
  • 3-ETHYL-4-NITROPYRIDINE 1-OXIDE
  • 3-Bromo-4-nitropyridine 1-oxide
  • 3-Fluoro-4-nitropyridine 1-oxide