2,2-Dihydroxy-1-phenylethan-1-one

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Names

[ CAS No. ]:
1075-06-5

[ Name ]:
2,2-Dihydroxy-1-phenylethan-1-one

[Synonym ]:
2,2-dihydroxyacetophenone
phenylglyoxyl monohydrate
2,2-dihydroxy-1-phenyl-ethanon
2,2-DIHYDROXY-1-PHENYL-ETHANONE
MFCD00149499
EINECS 214-036-1
PHENYLGLYOXAL
phenylglyoxal hemiacetal
2,2-dihydroxy-1-phenylethan-1-one
BENZOYLFORMALDEHYDE MONOHYDRATE
PHENYLGLYOXAL HYDRATE
2,2-dihydroxy-acetophenon
Phenylglyoxal Monohydrate
dihydroxy acetophenone

Chemical & Physical Properties

[ Density]:
1.307 g/cm3

[ Boiling Point ]:
142 °C125 mm Hg(lit.)

[ Melting Point ]:
76-79 °C(lit.)

[ Molecular Formula ]:
C8H8O3

[ Molecular Weight ]:
152.14700

[ Flash Point ]:
142°C/125mm

[ Exact Mass ]:
152.04700

[ PSA ]:
43.37000

[ LogP ]:
1.00390

[ Vapour Pressure ]:
0.00469mmHg at 25°C

[ Index of Refraction ]:
1.59

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5775180
CHEMICAL NAME :
Ethanone, 2,2-dihydroxy-1-phenyl-
CAS REGISTRY NUMBER :
1075-06-5
BEILSTEIN REFERENCE NO. :
2437741
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H8-O3
MOLECULAR WEIGHT :
152.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 1,365,1959

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MD3260000

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetophenone
  • Phenylglyoxal
  • Phenylacetylene
  • Glycolophenone
  • PHENYL DIAZOMETHYL KETONE
  • phenylene-ethylene
  • (2S)-2-amino-5-(((2R)-1-((carboxymethyl)amino)-3-((1-hydroxy-2-oxo-2-phenylethyl)thio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid
  • 2-hydroxy-2-((2-hydroxyethyl)thio)-1-phenylethan-1-one

DownStream

  • 2,5-Diphenyloxazole
  • 2-(4-bromophenyl)imino-1-phenylethanone
  • styrene glycol
  • Phenylglyoxylic acid
  • α-(Piperidinoimino)acetophenone
  • Oxazole,2-(4-chlorophenyl)-5-phenyl-
  • 6-phenyl-2H-1,2,4-triazin-3-one
  • Methyl (2S)-hydroxy(phenyl)acetate
  • (R)-methyl mandelate
  • 4-PHENYLIMIDAZOLE

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Inhibition of Hageman factor, plasma thromboplastin antecedent, thrombin and other clotting factors by phenylglyoxal hydrate (38500).

Proc. Soc. Exp. Biol. Med. 148(1) , 177-82, (1975)

Exposure of purified Hageman factor (HF, Factor XII) to phenylglyoxal hydrate (PHG), an agent reacting with arginine residues in protein, inhibited its coagulant properties upon subsequent exposure of...

Reaction of phenylglyoxal with arginine groups in D-amino-acid oxidase from Rhodotorula gracilis.

J. Biol. Chem. 269 , 17809, (1994)

D-Amino-acid oxidase from Rhodotorula gracilis was irreversibly inactivated by phenylglyoxal in a biphasic process. The fast phase was completed in less than 1 min. Its extent was linearly dependent o...

Specific arginine modification at the phosphatase site of muscle carbonic anhydrase.

Biochemistry 24(3) , 635-40, (1985)

Mammalian carbonic anhydrase III has previously been shown to catalyze the hydrolysis of p-nitrophenyl phosphate in addition to possessing the conventional CO2 hydratase and p-nitrophenylacetate ester...


More Articles

Related Compounds

  • 2,2-dihydroxy-1-phenylpropan-1-one
  • 2-(2-fluorophenyl)-1-phenylethan-1-one
  • 2,2-diiodo-1-phenylethan-1-one
  • 2-(2-acetylcyclohexyl)-1-phenylethan-1-one
  • 2-(2-bromophenoxy)-1-phenylethan-1-one
  • 2-(2-iminothiazolidin-3-yl)-1-phenylethan-1-one monohydrochloride