Exemestane

Suppliers

Names

[ Name ]:
Exemestane

[Synonym ]:
Exemestan
6-Methylenandrosta-1,4-diene-3,17-dione
(8R,9S,10R,13S,14S)-10,13-diméthyl-6-méthylidène-7,8,9,10,11,12,13,14,15,16-décahydro-3H-cyclopenta[a]phénanthrène-3,17(6H)-dione
6-methylenandrost-1,4-diene-3,17-dione
Aromasin
Exemestane
androsta-1,4-diene-6-methylene-3,17-dione
(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione
Exemestance
6-Methylene-androsta-1,4-diene-3,17-dione
MFCD00866994
6-Methyleneandrosta-1,4-diene-3,17-dione
EXALAMIDE
6-methylideneandrosta-1,4-diene-3,17-dione
Androsta-1,4-diene-3,17-dione, 6-methylene-
(8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methyliden-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthren-3,17(6H)-dion

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
453.7±45.0 °C at 760 mmHg

[ Melting Point ]:
155.13°C

[ Molecular Formula ]:
C₂₀H₂₄O₂

[ Molecular Weight ]:
296.403

[ Flash Point ]:
169.0±25.7 °C

[ Exact Mass ]:
296.177643

[ PSA ]:
34.14000

[ LogP ]:
3.11

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
Store at -20°C

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H319-H360

[ Precautionary Statements ]:
P201-P305 + P351 + P338-P308 + P313

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
60-61-51

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2937900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

6-Methyleneandrost-4-ene-3,17-dione
((8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl methanesulfonate
Methylene boldenone
Carbon
tert-Butanol
Boldenon
androsta-1,4-diene-3,17-dione
1α,3-dipyrrolidinylandrosta-3,5-dien-17-one
Dehydroepiandrosterone

DownStream

Customs

[ HS Code ]: 2937900090

[ Summary ]:
HS: 2937900090 Tax rebate rate:9.0% Supervision conditions:q(report of inspection of soundness on import medicines) VAT:17.0% MFN tariff:4.0% General tariff:30.0%

Articles

High throughput quantification of prohibited substances in plasma using thin film solid phase microextraction.

J. Chromatogr. A. 1374 , 40-9, (2014)

Simple, fast and efficient sample preparation approaches that allow high-throughput isolation of various compounds from complex matrices are highly desired in bioanalysis. Particularly sought are meth...

Synergistic effects of combined treatment with simvastatin and exemestane on MCF-7 human breast cancer cells.

Mol. Med. Report. 12 , 456-62, (2015)

Breast cancer is associated with high levels of incidence, morbidity and mortality; therefore, the identification of effective chemopreventive strategies is crucial. It is important for clinicians to ...

Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.

N. Engl. J. Med. 371(2) , 107-18, (2014)

Adjuvant therapy with an aromatase inhibitor improves outcomes, as compared with tamoxifen, in postmenopausal women with hormone-receptor-positive breast cancer.In two phase 3 trials, we randomly assi...

Exemestane Impurity 1
17β-Hydroxy Exemestane
1,2-Dihydro Exemestane
17|A-Hydroxy Exemestane
6-Hydroxymethyl Exemestane
EXEMESTANE RELATED COMPOUND
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
methyl 1-methyl-5-[(piperidin-3-yl)methyl]-1H-pyrrole-2-carboxylate
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide