vinyl acetate

Names

[ CAS No. ]:
108-05-4

[ Name ]:
vinyl acetate

[Synonym ]:
acetic acid,vinyl ester
Acetic Acid Vinyl Ester Monomer
MFCD00008713
acetic acid,ethenyl ester
Acetoxyethylene
Vinyl Acetate Monomer
EINECS 203-545-4
Vinyl acetate

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
72.5±0.0 °C at 760 mmHg

[ Melting Point ]:
-93 °C

[ Molecular Formula ]:
C₄H₆O₂

[ Molecular Weight ]:
86.089

[ Flash Point ]:
-6.7±0.0 °C

[ Exact Mass ]:
86.036781

[ PSA ]:
26.30000

[ LogP ]:
0.73

[ Vapour density ]:
3 (vs air)

[ Vapour Pressure ]:
118.5±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.390

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
23 g/L (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK0875000

CHEMICAL NAME :: Acetic acid, vinyl ester

CAS REGISTRY NUMBER :: 108-05-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 65

MOLECULAR FORMULA :: C4-H6-O2

MOLECULAR WEIGHT :: 86.10

WISWESSER LINE NOTATION :: 1VO1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11400 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 6200 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Liver - fatty liver degeneration

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg/30W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/6H/15D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/6H/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ppm/4H/1Y-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg/20W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 ppm/6H/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 ppm/6H/2Y-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 ppm/6H/5D/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 ppm/6H/5D/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg/D

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 91 gm/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,4816,1985 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 53 mg/m3 (15 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 35 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,443,1995 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,113,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,113,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,443,1995 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,443,1995 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (30 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,276,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (35 mg/m3);STEL 20 ppm (70 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (35 mg/m3);STEL 20 ppm (70 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (35 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-SWEDEN:TWA 10 ppm (35 mg/m3);STEL 15 ppm (50 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (35 mg/m3);STEL 20 ppm (70 mg/m3) JAN 1993 OEL-TURKEY:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO VINYL ACETATE-air:CL 4 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 76420 No. of Facilities: 5046 (estimated) No. of Industries: 62 No. of Occupations: 59 No. of Employees: 50282 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6624 No. of Facilities: 6264 (estimated) No. of Industries: 79 No. of Occupations: 71 No. of Employees: 129024 (estimated) No. of Female Employees: 36642 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H332-H335-H351-H412

[ Precautionary Statements ]:
P210-P261-P273-P281

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S16-S23-S29-S33-S45-S36/37-S7

[ RIDADR ]:
UN 1301 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
AK0875000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2915320000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

ethene
acetic acid
1,1-Ethanediol Diacetate
ch3cho
1-(2-Methylphenyl)-2-methyl-2-propanol
Ethyl acrylate TOP1 supplier
oxygen
vinyl alcohol
Acetyl chloride
Acetylene

DownStream

(E)-3-(5-methylfuran-2-yl)prop-2-enal
acetic acid,cyclohex-3-en-1-ol
1,3-bis(ethenyl)pyrimidine-2,4-dione
(2S)-3-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-2-METHYLPROPAN-1-OL
2-CHLORO-1-(3-CHLORO-PHENYL)-ETHANOL
(S)-2-CHLORO-1-(3-CHLORO-PHENYL)-ETHNOL
1-imidazol-1-ylethyl acetate

Customs

[ HS Code ]: 2915390090

[ Summary ]:
2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

Articles

Sub-micronic capsules based on gelatin and poly(maleic anhydride-alt-vinyl acetate) obtained by interfacial condensation with potential biomedical applications.

PLoS ONE 1st ed., 6 , (2011)

New sub-micronic capsules based on a copolymer of maleic anhydride-alt-vinyl acetate and a natural polymer (gelatin) using an interfacial condensation method were obtained. Sub-micronic capsules were ...

Easy preparation of enantiomerically enriched heteroaromatic alcohols through lipase-catalyzed acylation with succinic anhydride under unconventional activation.

Bioprocess Biosyst. Eng. 38 , 1579-88, (2015)

This study reports the lipase-catalyzed resolution of heteroaromatic secondary alcohols by succinic anhydride under different activation conditions by convenient procedure with succinic anhydride. The...

Regioselective alcoholysis of silychristin acetates catalyzed by lipases.

Int. J. Mol. Sci. 16 , 11983-95, (2015)

A panel of lipases was screened for the selective acetylation and alcoholysis of silychristin and silychristin peracetate, respectively. Acetylation at primary alcoholic group (C-22) of silychristin w...

vinyl acetate-d6
poly(vinyl acetate)
ethyl-vinyl acetate
ALLYL VINYL ACETATE
Ethylene Vinyl Acetate
.1-acetylvinyl acetate
N-Hydroxy-1-oxo-1,2-dihydro-5-isoquinolinecarboximidamide
(5-(Pyrrolidin-1-yl)furan-2-yl)methanamine
(2-Cyclopentyl-1,3-oxazol-4-yl)methanamine
(2-Ethoxy-3-fluorophenyl)methanamine
4-Pyridinemethanamine, 2-(cyclobutyloxy)-I+/--methyl-, (I+/-S)-
2,2-Difluoro-2-phenoxyethan-1-amine
(1-Phenyl-1H-imidazol-5-yl)methanamine
2-Methoxy-2-(pyridin-2-yl)propan-1-amine
2-Methoxy-2-(pyridin-3-yl)propan-1-amine
6,11-Dimethyl-6H-quinindolin-2-amine

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