Malonamide

Suppliers

Names

[ CAS No. ]:
108-13-4

[ Name ]:
Malonamide

[Synonym ]:
Malonamide
Methylenebisformamide
Propanediamide
METHYLENEDIFORMAMIDE
Malondiamide
EINECS 203-553-8
MFCD00008034
Malonic acid diamide
MALONIC DIAMIDE
Malonodiamide
Malonyldiamide
Carboxamidoacetamide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
460.9±28.0 °C at 760 mmHg

[ Melting Point ]:
172-175 °C(lit.)

[ Molecular Formula ]:
C3H6N2O2

[ Molecular Weight ]:
102.092

[ Flash Point ]:
232.5±24.0 °C

[ Exact Mass ]:
102.042931

[ PSA ]:
86.18000

[ LogP ]:
-2.54

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.491

[ Water Solubility ]:
180 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON9125000
CHEMICAL NAME :
Malonamide
CAS REGISTRY NUMBER :
108-13-4
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H6-N2-O2
MOLECULAR WEIGHT :
102.11
WISWESSER LINE NOTATION :
ZV1VZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1383,1977

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
C

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
ON9125000

[ HS Code ]:
29241900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Malononitrile
  • 2-Cyanoacetamide
  • Diethyl malonate
  • carbon suboxide
  • Ethyl 3-amino-3-oxopropanoate
  • Triethyl methanetricarboxylate
  • Ammonia
  • 2-benzylidenepropanediamide
  • ethyl 3-aminocrotonate

DownStream

  • 1,1,3,3-Propanetetracarboxamide
  • 2,6-dihydroxynicotinamide
  • DMBP
  • p-Anisic acid
  • Glycine,N-(aminocarbonyl)-
  • 2-benzylidenepropanediamide
  • 6-Hydroxy-2-(methoxymethyl)-4(3H)-pyrimidinone

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Altering in vivo macrophage responses with modified polymer properties.

Biomaterials 56 , 187-97, (2015)

Macrophage reprogramming has long been the focus of research in disease therapeutics and biomaterial implantation. With different chemical and physical properties of materials playing a role in macrop...

Influence of Ligand Shell Composition upon Interparticle Interactions in Multifunctional Nanoparticles.

Langmuir 31 , 12742-52, (2015)

The interactions of nanoparticles with biomolecules, surfaces, or other nanostructures are dictated by the nanoparticle's surface chemistry. Thus, far, shortcomings of syntheses of nanoparticles with ...

Effect of surface modification and macrophage phenotype on particle internalization.

Biomacromolecules 15(11) , 4102-10, (2014)

Material properties play a key role in the cellular internalization of polymeric particles. In the present study, we have investigated the effects of material characteristics such as water contact ang...


More Articles

Related Compounds

  • Bromomalonamide
  • malonamide ester
  • malonamide oxime
  • Methylmalonamide
  • Nitrilomalonamide
  • N-METHYL MALONAMIDE
  • 2-(5-Cyano-2-(6-(methoxycarbonyl)-7-methyl-3-oxo-8-(3-(trifluoromethyl)phenyl)-2,3,5,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrimidin-5-yl)phenyl)-N,N,N-trimethylethanaminium
  • N-(1-Cyano-1-cyclopropylethyl)-2-(2-ethylthiomorpholin-4-YL)acetamide
  • N-(2-Cyano-3-methylbutan-2-yl)-2-[(3-ethylsulfanylcyclopentyl)-methylamino]acetamide
  • N-((1-methyl-1,4,6,7-tetrahydropyrano[4,3-c]pyrazol-3-yl)methyl)-4-(trifluoromethoxy)benzamide
  • (6-Butoxypyridin-2-yl)boronic acid
  • 1-((1H-imidazol-4-yl)sulfonyl)-4-((4-fluorophenyl)sulfonyl)piperidine
  • N-(2,5-Dimethoxyphenyl)-2-{[2-(4-ethoxyphenyl)pyrazolo[1,5-A]pyrazin-4-YL]sulfanyl}acetamide
  • 2,4-dihydroxy-N-(4-(methylsulfonyl)phenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamide
  • 4-Bromo-6-ethoxypyrimidine
  • N-(2-(3-chlorophenyl)-2-methoxypropyl)-5-methylisoxazole-3-carboxamide
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.