Diisopropylamine

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Names

[ CAS No. ]:
108-18-9

[ Name ]:
Diisopropylamine

[Synonym ]:
Diisopropylamin
DIPA
EINECS 203-558-5
Diisoproplamine
Diisopropylamine,redistilled,AcroSeal
diisopropylanmine
Isodipropylamine
AURORA KA-7634
MFCD00008862

Chemical & Physical Properties

[ Density]:
0.722 g/mL at 25 °C(lit.)

[ Boiling Point ]:
84 °C(lit.)

[ Melting Point ]:
-61 °C

[ Molecular Formula ]:
C6H15N

[ Molecular Weight ]:
101.19000

[ Flash Point ]:
1.4 °F

[ Exact Mass ]:
101.12000

[ PSA ]:
12.03000

[ LogP ]:
1.78370

[ Vapour density ]:
3.5 (vs air)

[ Vapour Pressure ]:
74mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.392(lit.)

[ Water Solubility ]:
100 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
IM4025000
CHEMICAL NAME :
Diisopropylamine
CAS REGISTRY NUMBER :
108-18-9
LAST UPDATED :
199806
DATA ITEMS CITED :
41
MOLECULAR FORMULA :
C6-H15-N
MOLECULAR WEIGHT :
101.22
WISWESSER LINE NOTATION :
1Y1&MY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4800 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4200 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
2207 ppm/72M
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - cough Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2207 ppm/2.5H
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - cough Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2207 ppm/82M
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - cough Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
4200 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
48300 ppb/6H/14D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
261 ppm/7H/54D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
597 ppm/7H/9D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
597 ppm/7H/9D-I
TOXIC EFFECTS :
Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
REFERENCE :
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 3,129,1982 *** REVIEWS *** ACGIH TLV-TWA 21 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (20 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,87,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (21 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 5 ppm (20 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIISOPROPYLAMINE-air:10H TWA 5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 25850 No. of Facilities: 6803 (estimated) No. of Industries: 91 No. of Occupations: 99 No. of Employees: 91123 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 25850 No. of Facilities: 30 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 4577 (estimated) No. of Female Employees: 745 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H314-H331

[ Precautionary Statements ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R11;R20/22;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 1158 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
IM4025000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2921199020

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Propan-2-one oxime
  • isopropylamine
  • allyl bromide
  • N-propan-2-ylpropan-2-imine oxide
  • Methanol
  • 3-tert-butyl-1,1-diisopropylurea
  • N,N-Diisopropylcarbamidsaeure-(2-propenylester)
  • BIS(DIISOPROPYLAMINO)CHLOROPHOSPHINE
  • MeP[N(i-C3H7)2]2
  • N,N-diisopropyl-1-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-1-methylphosphinamine

DownStream

  • N,N-di(propan-2-yl)propanamide
  • Phenol, 4-nitro-, ion(1-) (9CI)
  • rac 5-Carboxy Tolterodine
  • N,N-di(propan-2-yl)-9H-fluoren-9-amine
  • 5-ethyl-3-methyl-N,N-di(propan-2-yl)-1,2-oxazole-4-carboxamide
  • (1,5-Cyclohexadien-1-yloxy)(trimethyl)silane
  • N,N-DIISOPROPYLANILINE
  • N,N-di(propan-2-yl)propan-2-amine
  • Benzene,1-methyl-4-[(4-methylphenyl)methyl]-
  • Lithium diisopropylamide

Customs

[ HS Code ]: 2921199020

[ Summary ]:
2921199020 diisopropylamine。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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Related Compounds

  • diisopropylamine-H+
  • diisopropylamine hbr
  • diisopropylamine-d14
  • Ethyldiisopropylamine
  • diisopropylamine-borane
  • Nitrosodiisopropylamine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 2,2-Difluoro-1-(1,3-thiazol-2-yl)cyclopropan-1-amine
  • (2S)-4-[1-(propan-2-yl)-1H-pyrazol-4-yl]butan-2-ol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 4-Bromo-2-methoxy-6-(2-methylbut-3-yn-2-yl)phenol