Isopropyl chloroformate

Suppliers

Names

[ CAS No. ]:
108-23-6

[ Name ]:
Isopropyl chloroformate

[Synonym ]:
EINECS 203-563-2
Chloroformic Acid Isopropyl Ester
propan-2-yl carbonochloridate
1-methylethyl chlorocarbonate
Isopropyl carbonochloridate
MFCD00075068
Carbonochloridic acid, 1-methylethyl ester
Isopropyl chloroformate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
108.3±9.0 °C at 760 mmHg

[ Melting Point ]:
-81ºC

[ Molecular Formula ]:
C4H7ClO2

[ Molecular Weight ]:
122.550

[ Flash Point ]:
25.0±11.8 °C

[ Exact Mass ]:
122.013458

[ PSA ]:
26.30000

[ LogP ]:
1.79

[ Vapour Pressure ]:
26.1±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.409

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ6475000
CHEMICAL NAME :
Formic acid, chloro-, isopropyl ester
CAS REGISTRY NUMBER :
108-23-6
BEILSTEIN REFERENCE NO. :
0506416
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C4-H7-Cl-O2
MOLECULAR WEIGHT :
122.56
WISWESSER LINE NOTATION :
GVOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 ppm/5H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 4,758,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 4,758,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
11300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 ppm/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Blood - hemorrhage Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (5 mg/m3) JAN 1993

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H304-H314-H317-H330-H336-H361d-H373

[ Precautionary Statements ]:
P210-P260-P280-P284-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;C:Corrosive;

[ Risk Phrases ]:
R11;R34;R48/20;R63;R65;R67

[ Safety Phrases ]:
S26-S36/37/39-S45-S62

[ RIDADR ]:
UN 3286 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
LQ6475000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2915130000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Triphosgene
  • Isopropanol
  • phosgene
  • Isopropyl formate
  • Diphosgene

DownStream

  • Isopropylcyclopentane
  • 1,2-cis-dimethylcyclohexane
  • trans-1,2-Dimethylcyclohexane
  • 3-(2,6-DICHLORO-PHENYL)-PROPAN-1-OL
  • isopropoxycarbonyl-l-valine
  • 4-bromo-2,5-dimethoxybenzene-1-sulfonyl chloride
  • Isopropyl Benzoate
  • Carbanilic acid,2-fluoro-5-(trifluoromethyl)-, isopropyl ester (7CI,8CI)
  • Carbanilic acid,4-fluoro-2-methyl-, isopropyl ester (8CI)
  • propan-2-yl N-(2-chlorophenyl)carbamate

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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Related Compounds

  • isopropyl 3-(1-(dimethylamino)-2-hydroxypropan-2-yl)-3-methyloxirane-2-carboxylate
  • isopropyl (Z)-3-iodoacrylate
  • isopropyl hydrogen maleate
  • Isopropyl {1-[(4-chlorophenyl)sulfonyl]-4-piperidinyl}carbamate
  • isopropyl 3-(1-(diethylamino)-2-hydroxypropan-2-yl)-3-methyloxirane-2-carboxylate
  • isopropyl 2,2-dimethylbutanoate
  • 2-[(3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(2-chlorobenzyl)acetamide
  • 4-chloro-N,N-dimethyl-2-sulfamoylbenzamide
  • 2,4-Bis(propan-2-yl)benzene-1-sulfonamide
  • N-benzyl-2-((3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)acetamide
  • 2-[(3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-butylphenyl)acetamide
  • 2-[(3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide
  • 2-((3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)-N-(2-methoxy-5-methylphenyl)acetamide
  • 2-((3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)-N-(2-chloro-4-methylphenyl)acetamide
  • 2-((3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)-N-(2,5-difluorophenyl)acetamide
  • 2-((3-butyl-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)-N-(5-chloro-2-methylphenyl)acetamide
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