2,6-Dimethylpyrazine

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Names

[ CAS No. ]:
108-50-9

[ Name ]:
2,6-Dimethylpyrazine

[Synonym ]:
FEMA No. 3273
Pyrazine, 2,6-dimethyl-
2,6-dimethyl-pyrazine
2,6-Dimethylparadiazine
Pyrazine,2,6-dimethyl
EINECS 203-589-4
2,6-Dimethylpyrazine
2,6-DiMepyz
3,5-Dimethylpyrazine
2,6-Dimethyl-1,4-diazine
2,6-Dimethylpiazine
MFCD00006148

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
155.6±0.0 °C at 760 mmHg

[ Melting Point ]:
35-40 °C(lit.)

[ Molecular Formula ]:
C₆H₈N₂

[ Molecular Weight ]:
108.141

[ Flash Point ]:
52.8±0.0 °C

[ Exact Mass ]:
108.068748

[ PSA ]:
25.78000

[ LogP ]:
0.64

[ Vapour Pressure ]:
3.9±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.504

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ2975000

CHEMICAL NAME :: Pyrazine, 2,6-dimethyl-

CAS REGISTRY NUMBER :: 108-50-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6N DNJ B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 2500 mg/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,581,1980

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H302-H315-H318-H335

[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R10;R22

[ Safety Phrases ]:
S16-S26-S39

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UQ2975000

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

tert-butyl 2-(hydroxyimino)propyl(prop-2-ynyl)carbamate
2,6-Dichloropyrazine
Methylmagnesium chloride
(1Z,2E)-1-(allylimino)propan-2-one oxime
D-(+)-Glucose
1-ethoxycarbonylamino-3,5-dimethyl-pyrazinium betaine
1,2-Diaminopropane
Glycerol

DownStream

6-Methylpyrazine-2-carboxylic acid
2-Chloro-3,5-dimethylpyrazine
3,5-Dimethyl-2-pyrazinamine
2-METHYL-6-VINYLPYRAZINE
2-[2-(3-fluorophenyl)ethenyl]-6-methylpyrazine
3,5-dimethyl-pyrazine-1-oxide
2,6-dimethyl-1-oxidopyrazin-1-ium
1-(2,5-dibromo-3-methylimidazol-4-yl)-2-(6-methylpyrazin-2-yl)ethanone
2-[(E)-1-(2,5-dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl]-6-methylpyrazine
2-[2-(5-bromo-3-methyl-2-methylsulfanylimidazol-4-yl)prop-2-enyl]-6-methylpyrazine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Influence of Free Amino Acids, Oligopeptides, and Polypeptides on the Formation of Pyrazines in Maillard Model Systems.

J. Agric. Food Chem. 63 , 5364-72, (2015)

Pyrazines are specific Maillard reaction compounds known to contribute to the unique aroma of many products. Most studies concerning the generation of pyrazines in the Maillard reaction have focused o...

Characterization of Volatile Flavor Compounds in Chinese Rice Wine Fermented from Enzymatic Extruded Rice.

J. Food Sci. 80 , C1476-89, (2015)

Enzymatic extrusion, instead of traditional steam cooking, to treat rice is an efficient and alternative pretreatment for Chinese rice wine fermentation. In order to determine the formation of volatil...

Extension of a dynamic headspace multi-volatile method to milliliter injection volumes with full sample evaporation: Application to green tea.

J. Chromatogr. A. 1421 , 103-13, (2015)

An extension of multi-volatile method (MVM) technology using the combination of a standard dynamic headspace (DHS) configuration, and a modified DHS configuration incorporating an additional vacuum mo...