Dimethyl malonate

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Names

[ CAS No. ]:
108-59-8

[ Name ]:
Dimethyl malonate

[Synonym ]:
dimethyl propanedioate
Propanedioic acid, dimethyl ester
Dimethyl malonate
MFCD00008460
Malonic acid dimethyl ester
methyl malonate
EINECS 203-597-8
Malonic acid, dimethyl ester

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
177.1±8.0 °C at 760 mmHg

[ Melting Point ]:
−62 °C(lit.)

[ Molecular Formula ]:
C5H8O4

[ Molecular Weight ]:
132.115

[ Flash Point ]:
90.0±0.0 °C

[ Exact Mass ]:
132.042252

[ PSA ]:
52.60000

[ LogP ]:
-0.36

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
1.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.402

[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Flammable.

[ Water Solubility ]:
negligible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OO0950000
CHEMICAL NAME :
Malonic acid, dimethyl ester
CAS REGISTRY NUMBER :
108-59-8
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H8-O4
MOLECULAR WEIGHT :
132.13
WISWESSER LINE NOTATION :
1OV1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,363,1979 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5331 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,363,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
1

[ RTECS ]:
OO0950000

[ HS Code ]:
29171910

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl chloroacetate
  • Methanol
  • Malonic acid
  • Chloromethane
  • Disodium malonate
  • 4-Chlorophenol
  • 3-Methoxy-3-oxopropanoic acid
  • Methyl chloroformate
  • carbon monoxide
  • Sodium Methylate

DownStream

  • dimethyl 2-(4-oxocyclopent-2-en-1-yl)propanedioate
  • DIMETHYL 2-ALLYL-2-(PROP-2-YN-1-YL)MALONATE
  • N,N''-DIBENZYL-MALONAMIDE
  • PROPANEDIOIC ACID, 2-(3-OXOCYCLOPENTYL)-, 1,3-DIMETHYL ESTER
  • 1,1,2,2-Ethenetetracarboxylicacid, 1,1,2,2-tetramethyl ester
  • hexamethyl propane-1,1,2,2,3,3-hexacarboxylate
  • tetramethyl 1-methoxyethane-1,1,2,2-tetracarboxylate
  • 1,1,2,2-Ethanetetracarboxylic acid, tetramethyl ester
  • dimethyl 2,2-dimethoxypropanedioate
  • tetramethyl 1-iodo-2-methoxyethanetetracarboxylate

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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Related Compounds

  • dimethyl malonate
  • dimethyl malonate
  • K[dimethyl malonate]
  • sodium dimethyl malonate
  • methyl dimethyl malonate
  • sodium dimethyl malonate
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  • N-(2-acetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-fluoro-4-methoxybenzenesulfonamide
  • 3,4-dimethoxy-N-(2-propionyl-1,2,3,4-tetrahydroisoquinolin-7-yl)benzenesulfonamide
  • 3-fluoro-N-(2-isobutyryl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxybenzenesulfonamide
  • N-(2-isobutyryl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxy-2-methylbenzenesulfonamide
  • N-(2-(furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-2,5-dimethoxybenzenesulfonamide
  • N-(2-(furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3,4-dimethoxybenzenesulfonamide
  • N-[2-(furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-4-methoxy-3-methylbenzene-1-sulfonamide
  • N-(2-(furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-methoxy-5-methylbenzenesulfonamide
  • 3-fluoro-N-(2-(furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxybenzenesulfonamide
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