1,3,5-Trichlorobenzene

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Names

[ CAS No. ]:
108-70-3

[ Name ]:
1,3,5-Trichlorobenzene

[Synonym ]:
1,3,5-TRICHLORO-BENZENE
s-Trichlorobenzene
1,3,5,-Trichlorobenzene
Benzene, 1,3,5-trichloro-
sym-Trichlorobenzene
1,3,5-Trichlorobenzene
3,5-dichlorophenyl chloride
MFCD00000585
Benzene,1,3,5-trichloro
EINECS 203-608-6

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
211.3±20.0 °C at 760 mmHg

[ Melting Point ]:
63 °C

[ Molecular Formula ]:
C6H3Cl3

[ Molecular Weight ]:
181.447

[ Flash Point ]:
126.7±0.0 °C

[ Exact Mass ]:
179.930038

[ LogP ]:
4.04

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.567

[ Stability ]:
Stable. Incompatible with acids, strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DC2100100
CHEMICAL NAME :
Benzene, 1,3,5-trichloro-
CAS REGISTRY NUMBER :
108-70-3
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C6-H3-Cl3
MOLECULAR WEIGHT :
181.44
WISWESSER LINE NOTATION :
GR CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7380 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Dominant lethal test

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
425 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2497 No. of Facilities: 60 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 1673 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H412

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R38

[ Safety Phrases ]:
S26-S36-S36/37-S61

[ RIDADR ]:
3077

[ WGK Germany ]:
3

[ RTECS ]:
DC2100100

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3,5-Dibromochlorobenzene
  • 1-Bromo-3,5-dichlorobenzene
  • 2,4,6-Trichloroaniline
  • 3,3-diethyl-1-(2,4,6-trichlorophenyl)triaz-1-ene
  • 3,5-Dichloroaniline
  • 1,2,3,5-Tetrachlorobenzene
  • Benzene,1,2,3,4,5-pentachloro-
  • bhc
  • γ-lindane
  • Hexachlorobenzene

DownStream

  • 1,2,3,4,5-pentachloro-6-[chloro-(2,4,6-trichlorophenyl)methyl]benzene
  • 2-[bis(2,4,6-trichlorophenyl)methyl]-1,3,5-trichlorobenzene
  • 3,5-Dichlorobiphenyl
  • 1,3-Dichlorobenzene
  • 2,2',4,4',6,6'-PCB
  • Isophthalic acid
  • Trimesic acid
  • 5-chlorobenzene-1,3-diol
  • 2,4,6-Trichlorobiphenyl
  • 2,6-Difluoroaniline

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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Related Compounds

  • 1,3,5-trichlorobenzene
  • 1,3,5-Trichlorobenzene-d3
  • 2-Iodo-1,3,5-trichlorobenzene
  • 2-butyl-1,3,5-trichlorobenzene
  • 2-azido-1,3,5-trichlorobenzene
  • 2-Bromo-1,3,5-trichlorobenzene
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2,3-Dichlorobenzenethiol sodium
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • [4-(Hydroxymethyl)phenyl]methanesulfonamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-Acetamido-5-(trifluoromethyl)benzoic acid