Cyanuric chloride

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Names

[ CAS No. ]:
108-77-0

[ Name ]:
Cyanuric chloride

[Synonym ]:
CYANURIC CHLORIDE FOR SYNTHESIS
CYANURIC CHLORIDE (2,4,6-TRICHLORO-1,3,5-TRIACINE)
1,3,5-Triazine, 2,4,6-trichloro-
chlorotriazine
Cyanuric chloride
Cyanuricchloride
trichloro-s-triazine
CYANURCHLORID
trichloro-1,3,5-triazine
2,4,6-TRICHLORO-S-TRIAZINE
1,3,5-TRIAZINE,2,4,6-TRICHLORO-
MFCD00006046
EINECS 203-614-9
2,4,6-Trichloro-1,3,5-triazine
2,4,6-TRICHLORO-[1,3,5]TRIAZINE

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
190.0±0.0 °C at 760 mmHg

[ Melting Point ]:
145-147 °C(lit.)

[ Molecular Formula ]:
C₃Cl₃N₃

[ Molecular Weight ]:
184.411

[ Flash Point ]:
214.4±8.8 °C

[ Exact Mass ]:
182.915787

[ PSA ]:
38.67000

[ LogP ]:
2.00

[ Vapour density ]:
6.36 (vs air)

[ Vapour Pressure ]:
0.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.586

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, water.

[ Water Solubility ]:
reacts

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ1400000

CHEMICAL NAME :: s-Triazine, 2,4,6-trichloro-

CAS REGISTRY NUMBER :: 108-77-0

BEILSTEIN REFERENCE NO. :: 0124246

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C3-Cl3-N3

MOLECULAR WEIGHT :: 184.41

WISWESSER LINE NOTATION :: T6N CN ENJ BG DG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,152,1972

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,152,1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 485 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/m3/2H

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4891,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07336 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Related to Chronic Data - death

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,119,1992

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1880 ug/m3/4H/11W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 gm/kg/73W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 12(4),78,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/73W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 12(4),78,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4559 No. of Facilities: 20 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2336 (estimated) No. of Female Employees: 299 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H317-H330-H335

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R14;R22;R26;R34;R43

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S46-S63-S28A

[ RIDADR ]:
UN 2670 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
XZ1400000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2933691000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Cyanogen chloride
2,4,6-tris(phenylsulfanyl)-1,3,5-triazine
s-triazine
Tricyanic acid
HYDROGEN CYANIDE
Dichloramine B
cyanogen
Diethyl dithiophosphoric acid
Phosphorodithioic acid,O,O-bis(1-methylethyl) ester

DownStream

2,4-dichloro-6-(2,4,6-trimethylphenoxy)-1,3,5-triazine
ISOCYANURIC ACID DIALLYL ESTER
2,4,6-TRIS(ALLYLOXY)-S-TRIAZINE
1-(4,6-dichloro-1,3,5-triazin-2-yl)-3,4-dihydro-2H-quinoline
Cyanogen chloride
2-Chloro-4,6-dimethoxy-1,3,5-triazine
2,4-Dichloro-6-methoxy-1,3,5-triazine
2,4,6-TRIMETHOXY-S-TRIAZINE
Deethyldeisopropylatrazine
2-Amino-4,6-dichlorotriazine

Customs

[ HS Code ]: 2933691000

[ Summary ]:
2933691000 2,4,6-trichloro-1,3,5-triazine。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.0%。General tariff:20.0%

Articles

Quantitative liquid chromatography-electrospray ionization-mass spectrometry analysis of amine-containing metabolites derivatized with cyanuric chloride and methylamine isotopologues.

J. Chromatogr. A. 1388 , 60-8, (2015)

Electrospray ionization (ESI) is the most useful interface for mass spectrometry associated with liquid chromatography (LC). However, analyses of polar metabolites become a challenge because the high ...

Metal Microporous Aromatic Polymers with Improved Performance for Small Gas Storage.

Chemistry 21 , 13357-63, (2015)

A novel metal-doping strategy was developed for the construction of iron-decorated microporous aromatic polymers with high small-gas-uptake capacities. Cost-effective ferrocene-functionalized micropor...

Microwave assisted synthesis of 2,2'-arylene-substituted bis(4H-3,1-benzoxazin-4-one) derivatives using the complex cyanuric chloride/N,N-dimethylformamide.

Molecules 17(10) , 11607-15, (2012)

A new and efficient method has been designed to prepare 2,2'-arylene-substituted bis(4H-3,1-benzoxazin-4-one) derivatives by using the mixture of cyanuric chloride and N,N-dimethylformamide in a micro...