taprostene

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Names

[ Name ]:
taprostene

[Synonym ]:
3-[(Z)-{(3aR,4R,5R,6aS)-4-[(1E,3S)-3-Cyclohexyl-3-hydroxy-1-propen-1-yl]-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-ylidene}methyl]benzoic acid
[3aR-[2Z,3aa,4a(1E,3S*)-5b,6aa]]-3-[[4-(3-Cyclohexyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzoic acid
a-[(2Z,3aR,4R,5R,6aS)-4-[(1E,3S)-3-Cyclohexyl-3-hydroxypropenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]-m-toluic acid
[(5Z,13E,9a,11a,15S)-2,3,4-Trinor-1,5-inter-m-phenylene-6,9-epoxy-11,15-dihydroxy-15-cyclohexyl-16,17,18,19,20-pentanor]prosta-5,13-dienoic acid
Benzoic acid, 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propen-1-yl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]-
taprostene

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
609.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₀O₅

[ Molecular Weight ]:
398.492

[ Flash Point ]:
209.2±25.0 °C

[ Exact Mass ]:
398.209320

[ PSA ]:
86.99000

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.670

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG5658000

CHEMICAL NAME :: Benzoic acid, 3-((4-(3-cyclohexyl-3-hydroxy-1-propenyl)hexahydro-5- hydroxy-2H-cyclopenta (b) furan-2-ylidene)methyl)-, (3aR-(2Z,3a-alpha,4-alpha(1E,3S*),5-beta,6a-alpha))-

CAS REGISTRY NUMBER :: 108945-35-3

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H30-O5

MOLECULAR WEIGHT :: 398.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 28 gm/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - ulceration or bleeding from large intestine Gastrointestinal - other changes

REFERENCE :: ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 46,71,1994