2-picoline

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Names

[ CAS No. ]:
109-06-8

[ Name ]:
2-picoline

[Synonym ]:
a-Picoline
2-picoline
methylpyridine
ALPHAP
2-Methylpyridine
MFCD00006332
2-Methyl pyridine
aPicolin
ai3-2409
2-methyl-pyridine
α-Picoline
monomethylpyridine
EINECS 203-643-7
Pyridine, 2-methyl-
o-Picoline

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
127.5±3.0 °C at 760 mmHg

[ Melting Point ]:
−70 °C(lit.)

[ Molecular Formula ]:
C₆H₇N

[ Molecular Weight ]:
93.127

[ Flash Point ]:
26.1±0.0 °C

[ Exact Mass ]:
93.057846

[ PSA ]:
12.89000

[ LogP ]:
1.19

[ Vapour density ]:
3.2 (vs air)

[ Vapour Pressure ]:
13.5±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.501

[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents, sulfuric acid, acids, metals, iron (II) sulfate, hydrogen peroxide. Hygroscopic.

[ Water Solubility ]:
MISCIBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ4900000

CHEMICAL NAME :: 2-Picoline

CAS REGISTRY NUMBER :: 109-06-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C6-H7-N

MOLECULAR WEIGHT :: 93.14

WISWESSER LINE NOTATION :: T6NJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 674 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 529 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 410 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1072 mg/kg/9W-I

TOXIC EFFECTS :: Blood - change in clotting factors Blood - thrombocytopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1810 ug/kg/26W-I

TOXIC EFFECTS :: Blood - change in clotting factors Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 7400 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,23,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3811 No. of Facilities: 132 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 11240 (estimated) No. of Female Employees: 1234 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302 + H332-H311-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P312

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R10;R20/21/22;R36/37

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2313 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TJ4900000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

piconol
ch3cho
2-Picoline 1-oxide
2-Bromo-6-methylpyridine
2-Bromo-3-methylpyridine
2-Picolinic acid
Formaldehyde
Propionaldehyde
2-Picolyl chloride
Benzaldehyde

DownStream

6-benzyl-2-methylpyridine
2-[5,6-dibutyl-1-methyl-3,4-bis(sulfanyl)pyridin-1-ium-2-yl]ethenone,iodide
2-[5,6-diethyl-1-methyl-3,4-bis(sulfanyl)pyridin-1-ium-2-yl]ethenone,iodide
2-(1-benzoylpyridin-2-ylidene)-1-phenylethanone
Pyridinium,2-methyl-1-(2-phenylethyl)-, bromide (1:1)
1-methyl-2-(2-methylsulfanyl-2-piperidin-1-ylethenyl)pyridin-1-ium,iodide
2-Methyl-6-(trifluoromethyl)pyridine
2-Methyl-5-(trifluoromethyl)pyridine
2-Methyl-4-(trifluoromethyl)pyridine
2-Methyl-3-(trifluoromethyl)pyridine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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