2-Chloropyridine

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Names

[ CAS No. ]:
109-09-1

[ Name ]:
2-Chloropyridine

[Synonym ]:
Pyridine,2-chloro-
α-Chloropyridine
2-Cl-pyridine
2-Chloro-pyridine
o-Chloropyridine
2-Chloropyridine
T6NJ BG
EINECS 203-646-3
MFCD00006228
Pyridine, 2-chloro-
2-pyridinyl chloride

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
170.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-46 °C

[ Molecular Formula ]:
C5H4ClN

[ Molecular Weight ]:
113.545

[ Flash Point ]:
65.0±0.0 °C

[ Exact Mass ]:
113.003227

[ PSA ]:
12.89000

[ LogP ]:
1.40

[ Vapour Pressure ]:
2.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.530

[ Water Solubility ]:
27 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US5950000
CHEMICAL NAME :
Pyridine, 2-chloro-
CAS REGISTRY NUMBER :
109-09-1
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C5-H4-Cl-N
MOLECULAR WEIGHT :
113.55
WISWESSER LINE NOTATION :
T6NJ BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 ppm/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
1980 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 301,57,1993

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H310 + H330-H315-H318-H335-H373-H410

[ Precautionary Statements ]:
P260-P280-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338 + P310-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23/24/25;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2822 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
US5950000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Bromopyridine
  • 2-Chloropyridine-N-oxide
  • 2-pyridone
  • pyridine oxide
  • 2-CHLORO-3-(TRIMETHYLSILYL)PYRIDINE
  • 2-chloro-6-(triMethylsilyl)pyridine
  • (6-chloropyridin-3-yl)-trimethylsilane
  • 2,6-Dichloropyridine 1-oxide
  • 2,2′-Dipyridyl disulfide
  • 5-ethyl-6-methyl-3-nitro-1H-pyridin-2-one

DownStream

  • 2-(3-METHOXY-BENZYL)-PIPERIDINE
  • 3-(2-PYRIDINYL)CYCLOHEXANONE
  • 4-(PYRIDIN-2-YL)BENZONITRILE
  • 1-(2-Pyridinyl)piperazine
  • Piperazine,1,4-di-2-pyridinyl-
  • 2-Chloro-3-pyridylboronic acid
  • 2-Fluoropyridine
  • 2-Chloro-6-fluoropyridine
  • 5-Nitro-2-phenylpyridine
  • [2-(Pyridin-2-ylthio)ethyl]amine dihydrochloride

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 2-Chloropyridine
  • 2-chloropyridine
  • 2-Chloropyridine-d4
  • 2-Chloropyridine-5-c
  • 2-Chloropyridine oxide
  • 2-chloropyridine,copper