2-Aminopyrimidine

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Names

[ CAS No. ]:
109-12-6

[ Name ]:
2-Aminopyrimidine

[Synonym ]:
2-pyrimidineamine
Pyrimidone imide
2-Pyrimidinemine
2-amino-pyrimidin
2-Aminopyrimidine
2-Pyrimidinamine
pyrimidin-2-amine
2-AMINO PYRIMIDINE
MFCD00006089
2-pyridiylamine
2-Pyrimidylamine
EINECS 203-648-4
2-AP
Pyrimidin-2-amin
2-amino-1,3-diazabenzene

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
148.0±23.0 °C at 760 mmHg

[ Melting Point ]:
122-126 °C(lit.)

[ Molecular Formula ]:
C4H5N3

[ Molecular Weight ]:
95.10

[ Flash Point ]:
43.3±22.6 °C

[ Exact Mass ]:
95.048347

[ PSA ]:
51.80000

[ LogP ]:
-0.89

[ Vapour Pressure ]:
4.3±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
-20°C

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV6326000
CHEMICAL NAME :
Pyrimidine, 2-amino-
CAS REGISTRY NUMBER :
109-12-6
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H5-N3
MOLECULAR WEIGHT :
95.12
WISWESSER LINE NOTATION :
T6N CNJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
50 mg/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 6,1623,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5674 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 14 No. of Employees: 1216 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
UV6326000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Bromopyrimidine
  • malonaldehyde
  • 2-Amino-4-chloropyrimidine
  • 1,1,3,3-Tetramethoxypropane
  • Guanidine hydrochloride
  • chloropyrimidine
  • 1,1,3-trimethoxy-3-propoxypropane
  • 1,1,3-trimethoxy-3-propan-2-yloxypropane
  • 1,3,3-trimethoxy-1-(n-butoxy)propane
  • 2-Amino-4,6-dichloropyrimidine

DownStream

  • 4-IMIDAZO[1,2-A]PYRIMIDIN-2-YL-BENZONITRILE
  • 2-CHLORO-N-PYRIMIDIN-2-YL-ACETAMIDE
  • 2-(chloromethyl)imidazo[1,2-a]pyrimidine
  • 2-(Chloromethyl)imidazo[1,2-a]pyridine
  • 5-chlorpyrimidin-2-amin
  • 3,5-dinitro-1-(pyrimidin-2-yl)pyridin-4(1H)-one
  • 4-Nitroaniline
  • N-pyrimidin-2-yl-1-thiophen-2-ylmethanimine
  • 2-(Pyrimidin-2-ylaminomethylene)-malonic acid diethyl ester

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cocrystals of 5-fluorocytosine. I. Coformers with fixed hydrogen-bonding sites.

Acta Crystallogr. B 68(Pt 4) , 431-43, (2012)

The antifungal drug 5-fluorocytosine (4-amino-5-fluoro-1,2-dihydropyrimidin-2-one) was cocrystallized with five complementary compounds in order to better understand its drug-receptor interaction. The...

Synthesis and Structural Study of Some Pyrimidinium Hexafluoridosilicates.

Acta Chim. Slov. 62 , 297-303, (2015)

The synthesis and spectroscopic characterization of some pyrimidinium hexafluoridosilicate salts with the formula (RH)2[SiF]6 (where R = 2-aminopyrimidine (1), cytosine (2) and 5-cyanocytosine (3)) is...

Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.

Eur. J. Med. Chem. 45 , 379-86, (2010)

A series of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidines derivatives were synthesized using a convenient synthetic route. We evaluate the isosteric replacement of methy...


More Articles

Related Compounds

  • 2-Aminopyrimidine
  • 2-aminopyrimidine N-oxide
  • 2-Aminopyrimidine-1-oxide
  • 4-BROMO-2-AMINOPYRIMIDINE
  • 2-Aminopyrimidine-4,5-diol
  • 2-Aminopyrimidine-4,6-diol
  • N-[(4-acetylphenyl)sulfonyl]acetamide
  • N-(5-methoxybenzo[d]thiazol-2-yl)-2-phenoxy-N-(pyridin-3-ylmethyl)benzamide
  • N-(4,5-dimethylbenzo[d]thiazol-2-yl)-N-(pyridin-3-ylmethyl)benzo[d]thiazole-2-carboxamide
  • N-(4,5-dimethylbenzo[d]thiazol-2-yl)-3-(2,5-dioxopyrrolidin-1-yl)-N-(pyridin-3-ylmethyl)benzamide
  • N-(4,5-dimethylbenzo[d]thiazol-2-yl)-2,2-diphenyl-N-(pyridin-3-ylmethyl)acetamide
  • N-(4,5-dimethylbenzo[d]thiazol-2-yl)-4-phenoxy-N-(pyridin-3-ylmethyl)benzamide
  • N-(4,5-dimethylbenzo[d]thiazol-2-yl)-2-phenoxy-N-(pyridin-3-ylmethyl)benzamide
  • 3-(6-Methyl-1h-benzo[d]imidazol-2-yl)-5-morpholinopyrazin-2-amine
  • Beta-Hydroxy-3-methylfentanyl-d3
  • N-(4,6-dimethylbenzo[d]thiazol-2-yl)-2-phenoxy-N-(pyridin-3-ylmethyl)benzamide
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