Loratadine Impurity 19

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Names

[ CAS No. ]:
109537-11-3

[ Name ]:
Loratadine Impurity 19

[Synonym ]:
4-(9-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
8-Dechloro-9-chloro Loratadine
Ethyl 4-(9-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxyate
Loratadine Impurity 19

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23ClN2O2

[ Molecular Weight ]:
382.88300

[ Exact Mass ]:
382.14500

[ PSA ]:
42.43000

[ LogP ]:
4.82570

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl chloroformate
  • 9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
  • N-tert-butyl-3-methylpyridine-2-carboxamide
  • 4-Chlorobenzyl chloride
  • magnesium,1-methylpiperidin-4-ide,chloride

DownStream

  • 8-Dechloro-9-chloro Desloratadine

Related Compounds

  • Desloratadine Impurity 19
  • Loratadine Impurity 24
  • Loratadine Impurity 3
  • Loratadine Impurity 23
  • Loratadine Impurity 14
  • Loratadine Impurity 25
  • 4-[4-(5-Fluoropyridin-2-yl)piperazin-1-yl]-2-methyl-6-(piperidin-1-yl)pyrimidine
  • 2-Methyl-3-[(1-{[5-(oxolan-3-yl)-1,3,4-oxadiazol-2-yl]methyl}piperidin-4-yl)methoxy]pyrazine
  • 4-({4-[(3-Fluoropyridin-2-yl)methyl]piperazin-1-yl}methyl)benzonitrile
  • 5-Bromo-3-fluoro-2-{3-[(1,3-thiazol-2-yloxy)methyl]piperidin-1-yl}pyridine
  • 4-Methyl-2-[4-(thiomorpholine-4-carbonyl)piperidin-1-yl]-1,3-benzothiazole
  • N-({4-fluoro-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]piperidin-4-yl}methyl)-2,2-dimethylpropanamide
  • 4-[4-(5-Chloropyrimidin-2-yl)piperazin-1-yl]-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidine
  • 3-Methyl-2-[3-(morpholine-4-carbonyl)pyrrolidin-1-yl]-3,4-dihydroquinazolin-4-one
  • N-ethyl-4-methyl-6-[4-(pyridin-4-yl)piperazin-1-yl]pyrimidin-2-amine
  • 4-(1-{[4-(Trifluoromethoxy)phenyl]methyl}azetidine-3-carbonyl)morpholine
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