Loratadine Impurity 19

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Names

[ CAS No. ]:
109537-11-3

[ Name ]:
Loratadine Impurity 19

[Synonym ]:
4-(9-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
8-Dechloro-9-chloro Loratadine
Ethyl 4-(9-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxyate
Loratadine Impurity 19

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23ClN2O2

[ Molecular Weight ]:
382.88300

[ Exact Mass ]:
382.14500

[ PSA ]:
42.43000

[ LogP ]:
4.82570

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl chloroformate
  • 9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
  • N-tert-butyl-3-methylpyridine-2-carboxamide
  • 4-Chlorobenzyl chloride
  • magnesium,1-methylpiperidin-4-ide,chloride

DownStream

  • 8-Dechloro-9-chloro Desloratadine

Related Compounds

  • Desloratadine Impurity 19
  • Loratadine Impurity 24
  • Loratadine Impurity 3
  • Loratadine Impurity 23
  • Loratadine Impurity 14
  • Loratadine Impurity 25
  • (1R,2S,5R)-1-((S)-But-3-en-2-yl)-2-isopropyl-5-methylcyclohexan-1-ol
  • 5-Fluoro-7-(3-methoxyazetidin-1-yl)-1,2,3,4-tetrahydroisoquinoline
  • tert-Butyl (5-amino-7-oxaspiro[3.5]nonan-2-yl)carbamate
  • (2S,4S)-1-benzyloxycarbonyl-4-cyano-pyrrolidine-2-carboxylic acid
  • (1R,2S)-1,2-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)cyclohexane
  • (S)-8-Bromo-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-ol
  • rel-((1S,4R,7S)-3-Bromo-1,7-dimethyl-2-oxobicyclo[2.2.1]heptan-7-yl)methanesulfonic acid
  • N-((11bS)-4-Oxido-2,6-bis(2,4,6-triisopropylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-P,P-diphenylphosphinic amide
  • Methyl-[5-(trifluoromethyl)pyridin-3-yl]carbamic acid
  • (E)-3-((21-Chloro-3,6,9,12,15-pentaoxahenicosyl)oxy)-N-(3-(2-fluorophenyl)-2-methylallyl)-4-methoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide
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