Loratadine Impurity 19

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Names

[ CAS No. ]:
109537-11-3

[ Name ]:
Loratadine Impurity 19

[Synonym ]:
4-(9-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
8-Dechloro-9-chloro Loratadine
Ethyl 4-(9-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxyate
Loratadine Impurity 19

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23ClN2O2

[ Molecular Weight ]:
382.88300

[ Exact Mass ]:
382.14500

[ PSA ]:
42.43000

[ LogP ]:
4.82570

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl chloroformate
  • 9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
  • N-tert-butyl-3-methylpyridine-2-carboxamide
  • 4-Chlorobenzyl chloride
  • magnesium,1-methylpiperidin-4-ide,chloride

DownStream

  • 8-Dechloro-9-chloro Desloratadine

Related Compounds

  • Desloratadine Impurity 19
  • Loratadine Impurity 24
  • Loratadine Impurity 3
  • Loratadine Impurity 23
  • Loratadine Impurity 14
  • Loratadine Impurity 25
  • 5-(chlorosulfonyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
  • tert-butyl N-(5-bromopyridin-2-yl)-N-(1-hydroxybutan-2-yl)carbamate
  • 5-(chlorosulfonyl)-1-(cyclopropylmethyl)-1H-pyrazole-4-carboxylic acid
  • 2-{4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]morpholin-3-yl}acetic acid
  • 2-chloro-5-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]benzoic acid
  • (2S)-3-[4-ethyl-6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-2-hydroxypropanoic acid
  • tert-butyl N-benzyl-N-[2-(4-ethylphenyl)-2-hydroxyethyl]carbamate
  • methyl 5-amino-1-(4-fluorophenyl)-4-(methoxymethyl)-1H-pyrazole-3-carboxylate
  • tert-butyl N-[(2,4-dimethoxyphenyl)methyl]-N-(2-hydroxyethyl)carbamate
  • tert-butyl N-[2-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate
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