AMG-221

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Names

[ CAS No. ]:
1095565-81-3

[ Name ]:
AMG-221

[Synonym ]:
5S-2-(bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
UNII-2T929W7AG8
4(5H)-Thiazolone,2-((1S,2S,4R)-bicyclo(2.2.1)hept-2-ylamino)-5-methyl-5-(1-methylethyl)-,(5S)
AMG 221
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

Chemical & Physical Properties

[ Molecular Formula ]:
C14H22N2OS

[ Molecular Weight ]:
266.40200

[ Exact Mass ]:
266.14500

[ PSA ]:
70.25000

[ LogP ]:
3.08460

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Iodopropane
  • 2-((1S,2S,4R)bicyclo[2.2.1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one
  • 2-Hydroxy-2,3-dimethylbutanoic acid
  • (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-isopropyl-5-me thyl-1,3-thiazol-4(5H)-one methanesulfonate (1:1)

DownStream

  • (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-isopropyl-5-me thyl-1,3-thiazol-4(5H)-one methanesulfonate (1:1)

Related Compounds

  • AMG-416
  • AMG-3969
  • AMG-076
  • AMG-Tie2-1
  • AMG 487 S-enantiomer
  • AMG 21629
  • 6,7,8,9-Tetrahydro-2-phenylpyrazolo[5,1-c][1,2,4]benzotriazine
  • 8-Methyl-3-(6-phenyl-3-pyridazinyl)-3,8-diazabicyclo[4.2.0]octane
  • N-(4-Amino-2,5-diethoxy-phenyl)-butyramide
  • (R)-4-carbobenzyloxy-1-(4,5-dichloro-2-nitrophenyl)-piperazine-2-carboxylic acid
  • Rel-(1R,6R,7S,8S,8aS)-octahydroindolizine-1,6,7,8-tetraol
  • 1-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid
  • rac-[(3R,4R)-1-benzyl-4-fluoropyrrolidin-3-yl]methanol, trans
  • 3-Aminomethyl-1-benzyl-4-chloropyrrolidine
  • 2-Methylhex-5-enamide
  • N-[2-Mercaptomethyl-3-Phenylpropionyl]-4-Aminobenzoic Acid
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