AMG-221

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Names

[ CAS No. ]:
1095565-81-3

[ Name ]:
AMG-221

[Synonym ]:
5S-2-(bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
UNII-2T929W7AG8
4(5H)-Thiazolone,2-((1S,2S,4R)-bicyclo(2.2.1)hept-2-ylamino)-5-methyl-5-(1-methylethyl)-,(5S)
AMG 221
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

Chemical & Physical Properties

[ Molecular Formula ]:
C14H22N2OS

[ Molecular Weight ]:
266.40200

[ Exact Mass ]:
266.14500

[ PSA ]:
70.25000

[ LogP ]:
3.08460

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Iodopropane
  • 2-((1S,2S,4R)bicyclo[2.2.1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one
  • 2-Hydroxy-2,3-dimethylbutanoic acid
  • (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-isopropyl-5-me thyl-1,3-thiazol-4(5H)-one methanesulfonate (1:1)

DownStream

  • (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-isopropyl-5-me thyl-1,3-thiazol-4(5H)-one methanesulfonate (1:1)

Related Compounds

  • AMG-416
  • AMG-3969
  • AMG-076
  • AMG-Tie2-1
  • AMG 487 S-enantiomer
  • AMG 21629