Tacrolimus

Suppliers

Names

[ Name ]:
Tacrolimus

[Synonym ]:
FK-506 monohydrate
FK 506 Monohydrate
FK-506 monohydrate,Tacrolimus
TacroliMus Monohydrate
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-, hydrate (1:1)
TACROLIMUS
(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-Allyl-1,14-dihydroxy-12-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-propen-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatr ;icyclo[22.3.1.0]octacos-18-ene-2,3,10,16-tetrone hydrate (1:1)
Tacrolimus (monohydrate)

Chemical & Physical Properties

[ Boiling Point ]:
871.7ºC at 760 mmHg

[ Melting Point ]:
127-129°

[ Molecular Formula ]:
C₄₄H₇₁NO₁₃

[ Molecular Weight ]:
822.033

[ Flash Point ]:
481ºC

[ Exact Mass ]:
821.492554

[ PSA ]:
187.59000

[ LogP ]:
4.51260

[ Vapour Pressure ]:
1.73E-35mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
Missing Phrase - N15.00950417

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 2811

[ RTECS ]:
KD4201200

[ Packaging Group ]:
III

Articles

The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.

Arch. Toxicol. 88(9) , 1695-709, (2014)

Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and ...

Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye.

Invest. Ophthalmol. Vis. Sci. 56(1) , 45-53, (2015)

To investigate the effect of FK-506 eye drops on Botulinum toxin B (BTX-B)-induced mouse dry eye.Forty-five CBA/J mice were followed up for 4 weeks after treatment with 0.025% FK-506, vehicle or 0.9% ...

Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models.

Arch. Pharm. Res. 38 , 813-25, (2015)

4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In...

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2-(azetidin-1-yl)-5-[(1E)-2-phenylethenyl]pyrimidine
N-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]cyclopropanecarboxamide
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N-{1-[(3,3-difluorocyclobutyl)methyl]piperidin-3-yl}cyclopropanecarboxamide
3,3-difluoro-N-(4-methoxy-2-methylphenyl)cyclobutane-1-carboxamide

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